PMID- 17446901
OWN - NLM
STAT- MEDLINE
DCOM- 20070802
LR  - 20081121
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Linking)
VI  - 127
IP  - 8
DP  - 2007 Aug
TI  - TNF-alpha gene promoter -238G>A and -308G>A polymorphisms alter risk of psoriasis 
      vulgaris: a meta-analysis.
PG  - 1886-92
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a major proinflammatory cytokine and 
      involved in the etiology of psoriasis. The -238G>A and -308G>A polymorphisms 
      influence the transcription of the TNF-alpha gene and have been implicated in 
      psoriasis risk. However, the results from the published studies on the 
      association between TNF-alpha polymorphisms and psoriasis risk are conflicting. 
      Our meta-analysis of a total of 997 psoriasis cases and 943 control subjects from 
      eight published case-control studies for the -238G>A polymorphism and of 1,156 
      psoriasis cases and 1,083 control subjects from 10 published case-control studies 
      for the -308G>A polymorphism showed that a significantly increased risk was 
      associated with the variant GA+AA genotypes of -238G>A, compared with the GG 
      genotype (odds ratio (OR) 2.60, 95% confidence interval (95% CI) 1.48-4.56), 
      whereas a significantly reduced psoriasis risk was associated with the variant 
      GA+AA genotypes of the -308G>A compared with the GG genotype (OR 0.57, 95% CI 
      0.45-0.71). Our findings suggest that TNF-alpha -238G>A and -308G>A polymorphisms 
      might be used as biomarkers for psoriasis risk prediction. A single larger study 
      with thousands of subjects and biochemical and biological characterization is 
      warranted to evaluate further the role of -238G>A and -308G>A polymorphisms and 
      psoriasis risk in a population of various ethnicities.
FAU - Li, Chunying
AU  - Li C
AD  - PLA Institute of Dermatology, Xijing Hospital, Fourth Military Medical 
      University, Shaanxi, China.
FAU - Wang, Gang
AU  - Wang G
FAU - Gao, Ying
AU  - Gao Y
FAU - Liu, Ling
AU  - Liu L
FAU - Gao, Tianwen
AU  - Gao T
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20070419
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - *Nuchal Cord
MH  - *Promoter Regions, Genetic
MH  - Psoriasis/etiology/*genetics
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2007/04/21 09:00
MHDA- 2007/08/03 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/08/03 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - S0022-202X(15)33529-6 [pii]
AID - 10.1038/sj.jid.5700822 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2007 Aug;127(8):1886-92. doi: 10.1038/sj.jid.5700822. Epub 
      2007 Apr 19.