PMID- 17448703
OWN - NLM
STAT- MEDLINE
DCOM- 20070831
LR  - 20071017
IS  - 1074-7427 (Print)
IS  - 1074-7427 (Linking)
VI  - 88
IP  - 1
DP  - 2007 Jul
TI  - Time-courses of Fos expression in rat hippocampus and neocortex following 
      acquisition and recall of a socially transmitted food preference.
PG  - 65-74
AB  - The present study examined expression of the immediate-early gene, c-Fos, 
      following acquisition, 48-h (recent) recall, and 1-week (remote) recall of a 
      socially transmitted food preference (STFP) in multiple brain regions implicated 
      in learning and memory. In comparisons with controls, trained Long-Evans rats had 
      increased Fos immunoreactivity in the ventral hippocampus following acquisition 
      and recent recall. In the parahippocampal cortices, Fos was increased in the 
      lateral entorhinal cortex after acquisition. In the orbitofrontal cortex, 
      increased Fos immunoreactivity was observed in the lateral orbital cortex 
      following both recent and remote recall and in the ventral orbital cortex 
      following remote recall, indicating a role for the orbitofrontal cortex in the 
      remote recall of STFP memory. In contrast, in the medial prefrontal cortex, 
      increased Fos-ir was found following acquisition in the prelimbic cortex and 
      following recent recall in the prelimbic and infralimbic cortices. No differences 
      in Fos expression were found between trained rats and controls in the dorsal 
      hippocampus, posterior parietal cortex, or amygdala. The present findings support 
      a time-limited role of the hippocampus in the acquisition and recall of STFP 
      memory and implicate neocortical regions involved in STFP acquisition, recent, 
      and remote recall.
FAU - Smith, Clayton A
AU  - Smith CA
AD  - Neuroscience Program, Tulane University, New Orleans, LA 70118, USA.
FAU - Countryman, Renee A
AU  - Countryman RA
FAU - Sahuque, Lacey L
AU  - Sahuque LL
FAU - Colombo, Paul J
AU  - Colombo PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070419
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Association Learning/physiology
MH  - Entorhinal Cortex/metabolism
MH  - Food Preferences/*physiology
MH  - Frontal Lobe/metabolism
MH  - Hippocampus/*metabolism
MH  - Imitative Behavior/physiology
MH  - Male
MH  - Mental Recall/*physiology
MH  - Neocortex/*metabolism
MH  - Prefrontal Cortex/metabolism
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - *Social Behavior
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 2007/04/24 09:00
MHDA- 2007/09/01 09:00
CRDT- 2007/04/24 09:00
PHST- 2007/02/12 00:00 [received]
PHST- 2007/03/06 00:00 [revised]
PHST- 2007/03/06 00:00 [accepted]
PHST- 2007/04/24 09:00 [pubmed]
PHST- 2007/09/01 09:00 [medline]
PHST- 2007/04/24 09:00 [entrez]
AID - S1074-7427(07)00026-3 [pii]
AID - 10.1016/j.nlm.2007.03.001 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2007 Jul;88(1):65-74. doi: 10.1016/j.nlm.2007.03.001. Epub 
      2007 Apr 19.