PMID- 17449459
OWN - NLM
STAT- MEDLINE
DCOM- 20070831
LR  - 20220317
IS  - 1029-8428 (Print)
IS  - 1029-8428 (Linking)
VI  - 11
IP  - 3-4
DP  - 2007 Apr
TI  - Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms.
PG  - 183-202
AB  - The amphetamines, including amphetamine (AMPH), methamphetamine (METH) and 
      3,4-methylenedioxymethamphetamine (MDMA), are among abused drugs in the US and 
      throughout the world. Their abuse is associated with severe neurologic and 
      psychiatric adverse events including the development of psychotic states. These 
      neuropsychiatric complications might, in part, be related to drug-induced 
      neurotoxic effects, which include damage to dopaminergic and serotonergic 
      terminals, neuronal apoptosis, as well as activated astroglial and microglial 
      cells in the brain. The purpose of the present review is to summarize the toxic 
      effects of AMPH, METH and MDMA. The paper also presents some of the factors that 
      are thought to underlie this toxicity. These include oxidative stress, 
      hyperthermia, excitotoxicity and various apoptotic pathways. Better understanding 
      of the cellular and molecular mechanisms involved in their toxicity should help 
      to generate modern therapeutic approaches to prevent or attenuate the long-term 
      consequences of amphetamine use disorders in humans.
FAU - Cadet, Jean Lud
AU  - Cadet JL
AD  - Molecular Neuropsychiatry Branch, DHHS/NIH/NIDA, Intramural Research Program, 
      5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. 
      jcadet@intra.nida.nih.gov
FAU - Krasnova, Irina N
AU  - Krasnova IN
FAU - Jayanthi, Subramaniam
AU  - Jayanthi S
FAU - Lyles, Johnalyn
AU  - Lyles J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Central Nervous System Stimulants/*toxicity
MH  - Dopamine/metabolism
MH  - Fever/chemically induced
MH  - Humans
MH  - Methamphetamine/toxicity
MH  - N-Methyl-3,4-methylenedioxyamphetamine/toxicity
MH  - Neurotoxicity Syndromes/genetics/pathology/physiopathology
MH  - Oxidative Stress/drug effects
RF  - 250
EDAT- 2007/04/24 09:00
MHDA- 2007/09/01 09:00
CRDT- 2007/04/24 09:00
PHST- 2007/04/24 09:00 [pubmed]
PHST- 2007/09/01 09:00 [medline]
PHST- 2007/04/24 09:00 [entrez]
AID - 10.1007/BF03033567 [doi]
PST - ppublish
SO  - Neurotox Res. 2007 Apr;11(3-4):183-202. doi: 10.1007/BF03033567.