PMID- 17449572
OWN - NLM
STAT- MEDLINE
DCOM- 20070531
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 137
IP  - 5
DP  - 2007 May
TI  - Exogenous oxidation of isomaltulose is lower than that of sucrose during exercise 
      in men.
PG  - 1143-8
AB  - Isomaltulose (ISO) is a disaccharide that is slowly digested, resulting in a slow 
      availability for absorption. The aim of this study was to compare the blood 
      substrate responses and exogenous carbohydrate (CHO) oxidation rates from orally 
      ingested sucrose (SUC) and ISO during moderate intensity exercise. We 
      hypothesized that the oxidation of ISO is lower compared with SUC, resulting in 
      lower plasma glucose and insulin concentrations and subsequent lower CHO and 
      higher fat oxidation rates. Ten trained men [maximal oxygen uptake (VO(2)max), 64 
      +/- 1 mL/(kg body mass.min)] cycled on 3 occasions for 150 min at 59 +/- 2% 
      VO(2)max and consumed either water (WAT) or 1 of 2 CHO solutions providing 1.1 
      g/min of CHO in the form of either SUC or ISO. Peak exogenous CHO oxidation rates 
      were higher (P < 0.05) during the SUC trial (0.92 +/- 0.03 g/min) than during the 
      ISO trial (0.54 +/- 0.05 g/min). Total endogenous CHO oxidation over the final 90 
      min of exercise was lower (P < 0.05) in the SUC trial (107 +/- 10 g) than in the 
      WAT (137 +/- 7 g) and ISO (127 +/- 9 g) trials. Fat oxidation was higher during 
      the WAT trial than during the SUC and ISO trials. ISO resulted in a lower plasma 
      insulin response at 30 min compared with SUC, whereas the glucose response did 
      not differ between the 2 CHO. Oxidation of ingested ISO was significantly less 
      than that of SUC, most likely due to the lower rate of digestion of ISO. A lower 
      CHO delivery and a small difference in plasma insulin may have resulted in higher 
      endogenous CHO use and higher fat oxidation during the ISO trial than during the 
      SUC trial.
FAU - Achten, Juul
AU  - Achten J
AD  - School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, B15 
      2TT, Birmingham, United Kingdom.
FAU - Jentjens, Roy L
AU  - Jentjens RL
FAU - Brouns, Fred
AU  - Brouns F
FAU - Jeukendrup, Asker E
AU  - Jeukendrup AE
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Blood Glucose)
RN  - 0 (Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Solutions)
RN  - 57-50-1 (Sucrose)
RN  - 67I334IX2M (Isomaltose)
RN  - V59P50X4UY (isomaltulose)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Carbohydrate Metabolism
MH  - Cross-Over Studies
MH  - Energy Metabolism
MH  - Exercise/*physiology
MH  - Fats/metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Humans
MH  - Insulin/blood
MH  - Isomaltose/administration & dosage/*analogs & derivatives/metabolism
MH  - Male
MH  - Osmolar Concentration
MH  - Oxidation-Reduction
MH  - Solutions/administration & dosage
MH  - Sucrose/administration & dosage/*metabolism
EDAT- 2007/04/24 09:00
MHDA- 2007/06/01 09:00
CRDT- 2007/04/24 09:00
PHST- 2007/04/24 09:00 [pubmed]
PHST- 2007/06/01 09:00 [medline]
PHST- 2007/04/24 09:00 [entrez]
AID - S0022-3166(22)09201-X [pii]
AID - 10.1093/jn/137.5.1143 [doi]
PST - ppublish
SO  - J Nutr. 2007 May;137(5):1143-8. doi: 10.1093/jn/137.5.1143.