PMID- 17449877
OWN - NLM
STAT- MEDLINE
DCOM- 20071207
LR  - 20161124
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 28
IP  - 9
DP  - 2007 May
TI  - Echocardiographic measures of acute haemodynamic response after cardiac 
      resynchronization therapy predict long-term clinical outcome.
PG  - 1143-8
AB  - AIMS: Although acute haemodynamic improvement in response to cardiac 
      resynchronization therapy (CRT) is reflective of a favourable cardiac contractile 
      response, there is limited information regarding not only its ability to predict 
      long-term clinical outcome but also cardiac-substrate-specific differences in the 
      prognostic value of this measure. METHODS AND RESULTS: Fifty-three heart failure 
      patients (69 +/- 11 years) with low left ventricle ejection fraction (LVEF) (22 
      +/- 6%), wide QRS (169 +/- 31 ms), and indications for CRT were included. There 
      were no significant differences in age, New York Heart Association (NYHA) class, 
      medications, QRS width, or LVEF between ischaemic (n = 37) and non-ischaemic (n = 
      16) groups. Echocardiograms were performed within 24 h of implantation with 
      device OFF and ON. Acute haemodynamic response was measured as LV dP/dt derived 
      from the CW Doppler of mitral regurgitation. Percentage change in dP/dt was used 
      to classify patients: high- (HR: DeltadP/dt > 25%) or poor-responders (PR: 
      DeltadP/dt <or= 25%). Clinical response to CRT was defined by a combined endpoint 
      of hospitalizations and all-cause mortality at 12 months. HR group had a 
      significantly better outcome compared to the PR group (P-value = 0.004) 
      irrespective of the aetiology of the cardiomyopathy. CONCLUSION: 
      Echocardiographic assessment of the acute haemodynamic response to CRT predicts 
      long-term clinical outcome in both ischaemic and non-ischaemic cardiomyopathy.
FAU - Tournoux, Francois B
AU  - Tournoux FB
AD  - Cardiac Arrhythmia Service and Cardiac Ultrasound Laboratory, Massachusetts 
      General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
FAU - Alabiad, Chrisfouad
AU  - Alabiad C
FAU - Fan, Dali
AU  - Fan D
FAU - Chen, Annabel A
AU  - Chen AA
FAU - Chaput, Miguel
AU  - Chaput M
FAU - Heist, Edwin Kevin
AU  - Heist EK
FAU - Mela, Theofanie
AU  - Mela T
FAU - Mansour, Moussa
AU  - Mansour M
FAU - Reddy, Vivek
AU  - Reddy V
FAU - Ruskin, Jeremy N
AU  - Ruskin JN
FAU - Picard, Michael H
AU  - Picard MH
FAU - Singh, Jagmeet P
AU  - Singh JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070421
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
CIN - Eur Heart J. 2007 May;28(9):1049-51. PMID: 17463008
MH  - Aged
MH  - *Cardiac Pacing, Artificial
MH  - Defibrillators, Implantable
MH  - Echocardiography, Doppler
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnostic imaging/*therapy
MH  - Humans
MH  - Male
MH  - Mitral Valve Insufficiency/etiology
MH  - Myocardial Ischemia/complications
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*therapy
EDAT- 2007/04/24 09:00
MHDA- 2007/12/08 09:00
CRDT- 2007/04/24 09:00
PHST- 2007/04/24 09:00 [pubmed]
PHST- 2007/12/08 09:00 [medline]
PHST- 2007/04/24 09:00 [entrez]
AID - ehm050 [pii]
AID - 10.1093/eurheartj/ehm050 [doi]
PST - ppublish
SO  - Eur Heart J. 2007 May;28(9):1143-8. doi: 10.1093/eurheartj/ehm050. Epub 2007 Apr 
      21.