PMID- 17451774
OWN - NLM
STAT- MEDLINE
DCOM- 20070718
LR  - 20181113
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 364
IP  - 1
DP  - 2007 Jul 20
TI  - Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus 
      monkey rhadinovirus.
PG  - 21-7
AB  - Several pathogenic human herpesviruses have recently been shown to express 
      virally encoded microRNAs in infected cells. Although the function of these 
      microRNAs is largely unknown, they are hypothesized to play a role in mediating 
      viral replication by downregulating cellular mRNAs encoding antiviral factors. 
      Here, we report the cloning and analysis of microRNAs encoded by Rhesus Monkey 
      Rhadinovirus (RRV), an animal virus model for the pathogenic human 
      gamma-herpesvirus Kaposi's Sarcoma-Associated Herpesvirus (KSHV). RRV expresses 
      several microRNAs that are encoded in the same genomic location as the previously 
      reported KSHV microRNAs, yet these microRNAs are unrelated in primary sequence. 
      These data set the stage for the mutational ablation and phenotypic analysis of 
      RRV mutants lacking one or more viral microRNAs.
FAU - Schafer, Alexandra
AU  - Schafer A
AD  - Department of Molecular Genetics and Microbiology and Center for Virology, Duke 
      University Medical Center, Durham, NC 27710, USA.
FAU - Cai, Xuezhong
AU  - Cai X
FAU - Bilello, John P
AU  - Bilello JP
FAU - Desrosiers, Ronald C
AU  - Desrosiers RC
FAU - Cullen, Bryan R
AU  - Cullen BR
LA  - eng
GR  - R56 AI067968/AI/NIAID NIH HHS/United States
GR  - AI063928/AI/NIAID NIH HHS/United States
GR  - R01 AI063928-01A1/AI/NIAID NIH HHS/United States
GR  - R01 AI067968-02/AI/NIAID NIH HHS/United States
GR  - R01 AI067968/AI/NIAID NIH HHS/United States
GR  - R01 AI063928/AI/NIAID NIH HHS/United States
GR  - R01 AI067968-01A1/AI/NIAID NIH HHS/United States
GR  - AI067968/AI/NIAID NIH HHS/United States
GR  - RR00168/RR/NCRR NIH HHS/United States
GR  - P51 RR000168/RR/NCRR NIH HHS/United States
GR  - K26 RR000168/RR/NCRR NIH HHS/United States
GR  - R01 AI063928-02/AI/NIAID NIH HHS/United States
GR  - R37 AI063928/AI/NIAID NIH HHS/United States
GR  - R56 AI063928/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070423
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Herpesvirus 8, Human/genetics
MH  - Humans
MH  - Macaca mulatta/*virology
MH  - MicroRNAs/chemistry/*genetics
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Nucleic Acid Conformation
MH  - Phenotype
MH  - RNA, Viral/chemistry/*genetics
MH  - Rhadinovirus/classification/*genetics
MH  - Species Specificity
PMC - PMC1941761
MID - NIHMS25519
EDAT- 2007/04/25 09:00
MHDA- 2007/07/19 09:00
PMCR- 2008/07/20
CRDT- 2007/04/25 09:00
PHST- 2007/02/05 00:00 [received]
PHST- 2007/02/21 00:00 [revised]
PHST- 2007/03/16 00:00 [accepted]
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/07/19 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
PHST- 2008/07/20 00:00 [pmc-release]
AID - S0042-6822(07)00190-0 [pii]
AID - 10.1016/j.virol.2007.03.029 [doi]
PST - ppublish
SO  - Virology. 2007 Jul 20;364(1):21-7. doi: 10.1016/j.virol.2007.03.029. Epub 2007 
      Apr 23.