PMID- 17451850
OWN - NLM
STAT- MEDLINE
DCOM- 20070719
LR  - 20220321
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 25
IP  - 22
DP  - 2007 May 30
TI  - Impact of a modified-live porcine reproductive and respiratory syndrome virus 
      vaccine intervention on a population of pigs infected with a heterologous 
      isolate.
PG  - 4382-91
AB  - The objectives of this study were to evaluate the effects of a therapeutic 
      vaccine intervention with a modified-live porcine reproductive and respiratory 
      syndrome virus (PRRSV) vaccine on the dynamics of a heterologous viral infection 
      in a population of pigs, and to determine the clinical and virological response 
      of previously exposed and vaccinated pigs against a second virulent heterologous 
      challenge. A population of 320 pigs were infected with a field isolate, PRRSV 
      MN-30100, alone or followed by Ingelvac PRRS MLV vaccine administered one to 
      three times at 30 days intervals beginning 1 week after infection. Vaccine 
      intervention reduced the duration of viral shedding, but did not reduce the viral 
      load in tissues or the proportion of persistently infected pigs. A different and 
      highly virulent field isolate, MN-184, was then given as a heterologous viral 
      challenge at 97 days after first exposure. Previously infected and vaccinated 
      pigs showed a significant reduction in clinical signs and enhanced weight gain 
      after the highly virulent challenge with PRRSV MN-184, but infection with and 
      shedding of the challenge isolate were not prevented.
FAU - Cano, Jean Paul
AU  - Cano JP
AD  - Swine Disease Eradication Center, University of Minnesota, College of Veterinary 
      Medicine, 385C Animal Science Veterinary Medicine Building, 1988 Fitch Avenue, 
      St. Paul, MN 55108, USA.
FAU - Dee, Scott A
AU  - Dee SA
FAU - Murtaugh, Michael P
AU  - Murtaugh MP
FAU - Pijoan, Carlos
AU  - Pijoan C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070403
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Viral)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*blood
MH  - Porcine Reproductive and Respiratory 
      Syndrome/immunology/physiopathology/*prevention & control/virology
MH  - Porcine respiratory and reproductive syndrome 
      virus/*classification/immunology/isolation & purification/*pathogenicity
MH  - RNA, Viral/blood
MH  - Swine
MH  - Vaccination/*veterinary
MH  - Viral Load
MH  - Viral Vaccines/*administration & dosage/genetics/immunology
MH  - Viremia/immunology/prevention & control/virology
MH  - Virulence
EDAT- 2007/04/25 09:00
MHDA- 2007/07/20 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/01/04 00:00 [received]
PHST- 2007/03/13 00:00 [revised]
PHST- 2007/03/20 00:00 [accepted]
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/07/20 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - S0264-410X(07)00361-1 [pii]
AID - 10.1016/j.vaccine.2007.03.031 [doi]
PST - ppublish
SO  - Vaccine. 2007 May 30;25(22):4382-91. doi: 10.1016/j.vaccine.2007.03.031. Epub 
      2007 Apr 3.