PMID- 17452258
OWN - NLM
STAT- MEDLINE
DCOM- 20070611
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 174
IP  - 2
DP  - 2007 Apr 15
TI  - 13q deletions in B-cell lymphoproliferative disorders: frequent association with 
      translocation.
PG  - 151-60
AB  - The 13q14 deletion is the most frequent abnormality in chronic lymphocytic 
      leukemias/small lymphocytic lymphomas, and this early rearrangement is observed 
      from the start of the disease. The systematic use of a panel of interphase 
      fluorescence in situ hybridization (FISH) may not reveal some probes (targeting 
      chromosomes 11q, 13q, 17p, and chromosome 12) structural abnormalities. In this 
      series, we analyzed metaphases by conventional cytogenetics, followed by 
      interphase and metaphase fluorescence in situ hybridization. We were able to 
      observe 17 cases of 13q translocations with deletions in eight of them. Three 
      distinct regions were involved by translocations in association with or without 
      deletions: a region centromeric to RB1 (13q11 approximately 13), a zone telomeric 
      to D13D25 (13q21 approximately 31), and a 13q14 region deliniated by RB1 and 
      D13S25. In this area, the deletion was variable: RB1 alone (one case), D13S319 
      approximately D13S25 (five cases), and from RB1 to D13S25 (two cases). The very 
      high frequency of 13q14 loss suggests that these deletions are of pathogenetic 
      importance, but, the importance of the translocations remains to be determined.
FAU - Struski, Stephanie
AU  - Struski S
AD  - Laboratoire d'Hematologie, Hopital de Hautepierre, Avenue Moliere, 67098 
      Strasbourg, France. stephanie.struski@chru-strasbourg.fr 
      <stephanie.struski@chru-strasbourg.fr>
FAU - Helias, Catherine
AU  - Helias C
FAU - Gervais, Carine
AU  - Gervais C
FAU - Audhuy, Bruno
AU  - Audhuy B
FAU - Zamfir, Alina
AU  - Zamfir A
FAU - Herbrecht, Raoul
AU  - Herbrecht R
FAU - Lessard, Michel
AU  - Lessard M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Chromosome Banding
MH  - Chromosome Breakage
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 5
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Male
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Translocation, Genetic
EDAT- 2007/04/25 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/25 09:00
PHST- 2006/09/18 00:00 [received]
PHST- 2006/12/05 00:00 [revised]
PHST- 2006/12/12 00:00 [accepted]
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - S0165-4608(06)00840-5 [pii]
AID - 10.1016/j.cancergencyto.2006.12.004 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 Apr 15;174(2):151-60. doi: 
      10.1016/j.cancergencyto.2006.12.004.