PMID- 17452727
OWN - NLM
STAT- MEDLINE
DCOM- 20070614
LR  - 20191210
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 62
IP  - 4
DP  - 2007 Apr
TI  - Dietary protein restriction decreases oxidative protein damage, peroxidizability 
      index, and mitochondrial complex I content in rat liver.
PG  - 352-60
AB  - Caloric restriction (CR) decreases oxidative damage, which contributes to the 
      slowing of aging rate. It is not known if such decreases are due to calories 
      themselves or specific dietary components. In this work, the ingestion of 
      proteins of Wistar rats was decreased by 40% below that of controls. After 7 
      weeks, the liver of the protein-restricted (PR) animals showed decreases in 
      oxidative protein damage, degree of membrane unsaturation, and mitochondrial 
      complex I content. The results and previous information suggest that the decrease 
      in the rate of aging induced by PR can be due in part to decreases in 
      mitochondrial reactive oxygen species production and DNA and protein oxidative 
      modification, increases in fatty acid components more resistant to oxidative 
      damage, and decreased expression of complex I, analogously to what occurs during 
      CR. Recent studies suggest that those benefits of PR could be caused, in turn, by 
      the lowered methionine intake of that dietary manipulation.
FAU - Ayala, Victoria
AU  - Ayala V
AD  - Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, 
      Spain.
FAU - Naudi, Alba
AU  - Naudi A
FAU - Sanz, Alberto
AU  - Sanz A
FAU - Caro, Pilar
AU  - Caro P
FAU - Portero-Otin, Manuel
AU  - Portero-Otin M
FAU - Barja, Gustavo
AU  - Barja G
FAU - Pamplona, Reinald
AU  - Pamplona R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Amino Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acids)
RN  - 0 (Peroxides)
RN  - 0 (Proteins)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 7.1.1.2 (Electron Transport Complex I)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Animals
MH  - Biomarkers/metabolism
MH  - *Diet, Protein-Restricted
MH  - Electron Transport Complex I/*metabolism
MH  - Electron Transport Complex IV/metabolism
MH  - Fatty Acids/metabolism
MH  - Homeostasis
MH  - Liver/*metabolism
MH  - Male
MH  - Mitochondria, Liver/metabolism
MH  - Oxidation-Reduction
MH  - Peroxides/*metabolism
MH  - Proteins/*metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2007/04/25 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - 62/4/352 [pii]
AID - 10.1093/gerona/62.4.352 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):352-60. doi: 
      10.1093/gerona/62.4.352.