PMID- 17452743
OWN - NLM
STAT- MEDLINE
DCOM- 20070614
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 62
IP  - 4
DP  - 2007 Apr
TI  - Evaluation of oxidative stress and effectiveness of low-dose glucocorticoid 
      therapy on exacerbation of chronic obstructive pulmonary disease.
PG  - 459-64
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) and its exacerbation are 
      considered to be related to oxidative stress. We determined the levels of 
      reactive oxygen metabolites (ROM) and a biological antioxidant potential (BAP) in 
      blood before and after the exacerbation. METHODS: For these determinations, the 
      Free Radical Analytical System 4 was used. Twenty-one male patients were divided 
      into two groups. RESULTS: Group A patients (n = 11, for whom the disease was 
      end-stage) showed high ROM levels and low BAP levels. Meanwhile, Group B patients 
      (n = 10, for whom the disease was not end-stage but the exacerbation was 
      repeated) exhibited variable ROM levels corresponding to the symptoms. Before the 
      exacerbation, ROM levels increased. After administering high-dose 
      glucocorticoids, the exacerbation disappeared and ROM levels decreased to the 
      baseline. To suppress the relapse, the Group B patients were medicated with 
      low-dose glucocorticoids by inhalation and systemic administration. Then, ROM 
      levels did not increase or the relapse did not occur. BAP levels continued to be 
      low, and were restored after a stable state was obtained. CONCLUSION: 
      Overproduction of ROM may precede exacerbation of COPD, and the low-dose 
      glucocorticoid therapy may be effective to suppress its overproduction and to 
      preserve COPD in a stable state.
FAU - Komatsu, Fumio
AU  - Komatsu F
AD  - The High Technology Research Center, Kagawa Nutrition University, Saitama, Japan. 
      komatsu@eiyo.ac.jp
FAU - Kudoh, Hideki
AU  - Kudoh H
FAU - Kagawa, Yasuo
AU  - Kagawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Antioxidants)
RN  - 0 (Glucocorticoids)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Administration, Inhalation
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Forced Expiratory Volume
MH  - Glucocorticoids/*administration & dosage/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Pulmonary Disease, Chronic Obstructive/blood/*drug 
      therapy/metabolism/*physiopathology
MH  - Reactive Oxygen Species/metabolism
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2007/04/25 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - 62/4/459 [pii]
AID - 10.1093/gerona/62.4.459 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):459-64. doi: 
      10.1093/gerona/62.4.459.