PMID- 17453372
OWN - NLM
STAT- MEDLINE
DCOM- 20070601
LR  - 20090512
IS  - 0284-186X (Print)
IS  - 0284-186X (Linking)
VI  - 46
IP  - 2
DP  - 2007
TI  - Nasopharyngeal carcinoma. Treatment planning with IMRT and 3D conformal 
      radiotherapy.
PG  - 214-20
AB  - The study was undertaken in order to compare dose plans for intensity-modulated 
      radiotherapy (IMRT) with 3D conformal radiotherapy (3D-CRT) dose plans in 
      patients with nasopharyngeal carcinoma (NPC). Clinical data from 20 consecutive 
      patients treated with IMRT are presented. For 11 patients 3D-CRT plans were made 
      and compared to the IMRT plans with respect to doses to the planning target 
      volumes (PTVs) and to organs at risk (OARs). For comparison of the conformation 
      of dose to defined target volumes the conformity index (CI) was used. Target 
      volume coverage and critical organ protection were significantly improved with 
      IMRT compared to 3D-CRT. One-year loco-regional control, distant metastasis-free 
      survival, and overall survival were 79%, 72%, and 80%. Two patients have had 
      recurrence in the clinical target volume (CTV) only and seven patients have 
      relapsed in distant organs and/or in head-and-neck areas outside the target 
      areas. The study confirms that IMRT is superior to 3D-CRT in the treatment of 
      NPC. As locoregional control of NPC improves we are facing an increasing number 
      of recurrences outside the irradiated area.
FAU - Kristensen, Claus A
AU  - Kristensen CA
AD  - Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Denmark. 
      andrup@rh.dk
FAU - Kjaer-Kristoffersen, Flemming
AU  - Kjaer-Kristoffersen F
FAU - Sapru, Wendy
AU  - Sapru W
FAU - Berthelsen, Anne K
AU  - Berthelsen AK
FAU - Loft, Annika
AU  - Loft A
FAU - Specht, Lena
AU  - Specht L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Carcinoma/mortality/*radiotherapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/mortality/*radiotherapy
MH  - Neoplasm Recurrence, Local/diagnosis
MH  - Radiotherapy, Conformal/*methods
MH  - *Radiotherapy, Intensity-Modulated
MH  - Treatment Outcome
EDAT- 2007/04/25 09:00
MHDA- 2007/06/02 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/06/02 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - 770513654 [pii]
AID - 10.1080/02841860600635862 [doi]
PST - ppublish
SO  - Acta Oncol. 2007;46(2):214-20. doi: 10.1080/02841860600635862.