PMID- 17454331
OWN - NLM
STAT- MEDLINE
DCOM- 20070515
LR  - 20071203
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 44
IP  - 3
DP  - 2007 Apr
TI  - The impact of comorbid atopic disease on asthma: clinical expression and 
      treatment.
PG  - 149-61
AB  - Clinically, asthma and allergic rhinitis involve separate regions of the 
      respiratory tract while representing a common underlying inflammatory syndrome. 
      Much evidence supports an epidemiologic association between the diseases, 
      paranasal sinus involvement in both conditions, and parallel relationship in 
      severity and treatment outcomes. Pathophysiologic mechanisms, including 
      immunoglobulin E (IgE)- mediated inflammation, are also shared. Blocking IgE with 
      the recombinant humanized monoclonal antibody omalizumab demonstrated clinical 
      efficacy in patients with upper and lower airway diseases. IgE blockade, 
      leukotriene modulation, and B-cell depletion therapy have all exhibited success 
      in chronic inflammation, reinforcing and expanding the beneficial role of 
      immunomodulation of global mediators.
FAU - Peters, Stephen
AU  - Peters S
AD  - Department of Medicine, Section on Pulmonary, Critical Care, Allergy & 
      Immunologic Diseases and the Center for Human Genomics, Wake Forest University 
      School of Medicine, Winston, NC 27157-1052, USA. sppeters@wfubmc.edu
LA  - eng
GR  - HL067663/HL/NHLBI NIH HHS/United States
GR  - HL069167/HL/NHLBI NIH HHS/United States
GR  - HL074225/HL/NHLBI NIH HHS/United States
GR  - HL076285/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Anti-Asthmatic Agents)
SB  - IM
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Asthma/*complications/epidemiology/*physiopathology/therapy
MH  - Dermatitis, Atopic/complications
MH  - Humans
MH  - Hypersensitivity/*complications
MH  - Prevalence
MH  - Rhinitis/complications
MH  - Sinusitis/complications
MH  - United States/epidemiology
RF  - 161
EDAT- 2007/04/25 09:00
MHDA- 2007/05/16 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/05/16 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - 777187474 [pii]
AID - 10.1080/02770900600925478 [doi]
PST - ppublish
SO  - J Asthma. 2007 Apr;44(3):149-61. doi: 10.1080/02770900600925478.