PMID- 17454605
OWN - NLM
STAT- MEDLINE
DCOM- 20070619
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 48
IP  - 3
DP  - 2007 Mar
TI  - Wilms' tumor gene (WT1) is predominantly expressed in clonal hematopoietic cells 
      in myelodysplastic syndromes.
PG  - 601-4
AB  - To determine the expression of Wilms' tumor gene (WT1) in clonal hematopoietic 
      cells in patients with myelodysplastic syndromes (MDS), immunochemistry labelling 
      (alkaline phosphatase anti-alkaline phosphatase) and fluorescence in situ 
      hybridization (FISH) were coperformed on bone marrow cytospins from 18 patients 
      whose abnormal karyotypes had been determined by G-binding analysis. Compared to 
      12 healthy donors, WT1 positive nucleated cells in MDS marrows were significantly 
      higher (t = 2.30; P = 0.032). Moreover, WT1 was expressed predominantly in MDS 
      clonal cells (with abnormal FISH signals) rather than in non-clonal cells 
      (residual normal cells) (t = 2.19; P = 0.043).
FAU - Li, Xiao
AU  - Li X
AD  - Department of Hematology, The Sixth People's Hospital Affiliated to Shanghai 
      Jiaotong University, Shanghai, China. lixiao3326@yahoo.com.cn
FAU - Wu, Lingyun
AU  - Wu L
FAU - Ying, Shaoxu
AU  - Ying S
FAU - Chang, Chunkang
AU  - Chang C
FAU - Pu, Quan
AU  - Pu Q
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (WT1 Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia, Refractory/genetics/metabolism
MH  - Anemia, Refractory, with Excess of Blasts
MH  - Case-Control Studies
MH  - Chromosome Aberrations
MH  - Clone Cells
MH  - Female
MH  - Gene Expression
MH  - Hematopoietic System/metabolism
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics/metabolism
MH  - WT1 Proteins/*genetics/metabolism
EDAT- 2007/04/25 09:00
MHDA- 2007/06/20 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/06/20 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - 773542385 [pii]
AID - 10.1080/10428190601110069 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2007 Mar;48(3):601-4. doi: 10.1080/10428190601110069.