PMID- 17454725
OWN - NLM
STAT- MEDLINE
DCOM- 20070725
LR  - 20131121
IS  - 0803-9488 (Print)
IS  - 0803-9488 (Linking)
VI  - 61
IP  - 2
DP  - 2007
TI  - The influence of educational information on depressed outpatients treated with 
      escitalopram: a semi-naturalistic study.
PG  - 109-14
AB  - This open-label multicentre semi-naturalistic study in Finland assessed the 
      impact of educational information on efficacy of 16-week treatment with 
      escitalopram (5-20 mg/day) in a patient population suffering from depression. 
      Patients were randomized single blind to receive educational information (n=79) 
      or no information (n=78) in addition to open-label escitalopram treatment. 
      Patients were assessed using the Montgomery-Asberg Depression Rating Scale 
      (MADRS), Clinical Global Impression - Severity and - Improvement (CGI-S and 
      CGI-I), Patient Global Evaluation (PGE), and Hopkins Symptom Checklist (SCL-90) 
      scales. Tolerability was assessed by the incidence of adverse events (AEs). A 
      total of 132 (84%) out of 157 patients completed the study, with similar 
      completer rates in both groups. There was no statistically significant effect of 
      educational information on the efficacy of escitalopram treatment, as measured by 
      MADRS, CGI and PGE. Mean MADRS total score was 25.3 at baseline, corresponding to 
      moderate to severe depression, and decreased to 7.9 at the end of the treatment 
      for both groups. The response rate (> or = 50% reduction in MADRS total score 
      from baseline) was 80% at the end of treatment for both groups. The clinical 
      relevance of the improvement was seen in CGI-I and PGE scores and there was a 
      strong correlation between the two scales, indicating agreement by both patients 
      and investigators. AEs were mostly mild and transient and 11 patients (7.0%) 
      dropped out of the study due to AEs, with similar incidence in both groups. 
      Escitalopram was effective and well tolerated in the treatment of depression over 
      a 16-week period in a semi-naturalistic setting, and an additional effect of 
      educational information could not be shown, possibly due to the high response to 
      treatment.
FAU - Leinonen, Esa
AU  - Leinonen E
AD  - Department of Psychiatry, Tampere University Hospital, University of Tampere, 
      Tampere, Finland. esa.leinonen@pshp.fi
FAU - Niemi, Heikki
AU  - Niemi H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0DHU5B8D6V (Citalopram)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Antidepressive Agents, Second-Generation/adverse effects/*therapeutic use
MH  - Citalopram/adverse effects/*therapeutic use
MH  - Depressive Disorder/*drug therapy/psychology/therapy
MH  - Female
MH  - Finland
MH  - Humans
MH  - Male
MH  - Outpatients/*education/psychology
MH  - Patient Education as Topic/*methods/statistics & numerical data
MH  - Program Evaluation/*methods
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Severity of Illness Index
MH  - Single-Blind Method
MH  - Treatment Outcome
EDAT- 2007/04/25 09:00
MHDA- 2007/07/26 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/07/26 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - 777119400 [pii]
AID - 10.1080/08039480701226088 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2007;61(2):109-14. doi: 10.1080/08039480701226088.