PMID- 17455264
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20070614
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 36
IP  - 1
DP  - 2007 Jul
TI  - Motor unit number estimates and quantitative motor unit analysis in healthy 
      subjects and patients with amyotrophic lateral sclerosis.
PG  - 62-70
AB  - Limitations associated with global measures of function in patients with 
      amyotrophic lateral sclerosis (ALS) and the qualitative nature of needle 
      electromyography have stimulated the development of alternate means of monitoring 
      disease severity and progression in ALS. Thus, the objective of this study was to 
      examine the ability of one these techniques, decomposition-based quantitative 
      electromyography (DQEMG), to obtain electrophysiological data, including motor 
      unit number estimates (MUNEs), from a group of patients with ALS. The first 
      dorsal interosseous and biceps brachii muscles were studied in 10 healthy 
      subjects and 9 patients with ALS. Following the acquisition of a maximum M wave, 
      needle- and surface-detected EMGs were collected simultaneously during 30-second 
      contractions performed at 10% of the maximum voluntary contraction force to 
      obtain motor unit potential (MUP) trains. DQEMG was then used to extract the 
      surface-detected MUP associated with each MUP train, the mean size of which was 
      divided into the maximum M wave to obtain a MUNE. The results suggest that 
      quantitative electrophysiological data obtained using DQEMG are representative of 
      the pathophysiological changes in the lower motor system in ALS patients, 
      supporting its use in studies documenting the natural history and progression of 
      the disease.
FAU - Boe, Shaun G
AU  - Boe SG
AD  - School of Kinesiology, University of Western Ontario, London, Ontario, Canada. 
      sboe@uwo.ca
FAU - Stashuk, Daniel W
AU  - Stashuk DW
FAU - Doherty, Timothy J
AU  - Doherty TJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Adult
MH  - Amyotrophic Lateral Sclerosis/*pathology/*physiopathology
MH  - Electric Stimulation/methods
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Neurons/*physiology
MH  - Muscle, Skeletal/*physiopathology
EDAT- 2007/04/25 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/04/25 09:00
PHST- 2007/04/25 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/04/25 09:00 [entrez]
AID - 10.1002/mus.20784 [doi]
PST - ppublish
SO  - Muscle Nerve. 2007 Jul;36(1):62-70. doi: 10.1002/mus.20784.