PMID- 17456983
OWN - NLM
STAT- MEDLINE
DCOM- 20070523
LR  - 20220330
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 71
IP  - 5
DP  - 2007 May
TI  - Cardiac troponin T vs other biochemical markers in patients with congestive heart 
      failure.
PG  - 631-5
AB  - BACKGROUND: Several pathologic processes can cause myocardial injury, which is 
      followed by cardiac remodeling and congestive heart failure (CHF). Cardiac 
      troponin T (cTnT), a specific and sensitive marker of myocardial injury, has been 
      related to long-term outcome in patients with CHF, so the relationship between 
      cTnT and other biochemical markers associated with the pathophysiology of CHF was 
      investigated in the present study. METHODS AND RESULTS: Between February 2004 and 
      December 2005, 145 consecutive hospitalized patients (mean left ventricular 
      ejection fraction (LVEF) 31.6+/-0.9%) with CHF were divided into low (<0.01 
      ng/ml) and high (> or =0.01 ng/ml) serum cTnT groups. Correlations with other 
      prognostic biochemical markers, including brain natriuretic peptide (BNP), type I 
      collagen C-terminal telopeptide (ICTP), procollagen type III peptide (PIIIP), 
      renin, norepinephrine (NOREPI), C-reactive protein (CRP), cholesterol, hemoglobin 
      (Hb), uric acid and HbA1c were examined. cTnT was high in 46 (32%) and low in 99 
      (68%) patients at baseline. Patients with high cTnT had abnormally high blood 
      concentrations of BNP (p<0.0001), ICTP (p<0.0001), PIIIP (p=0.0006), NOREPI 
      (p=0.0119), CRP (p=0.0003), uric acid (p=0.0026) and HbA1c (p=0.0361). In 
      contrast, concentrations of cholesterol and Hb were significantly lower in 
      patients with high cTnT (p=0.0319 and 0.0005, respectively). Death from or 
      rehospitalization for CHF occurred in 41% in the high vs 9% in the low cTnT group 
      (p=0.0002). Univariate analysis showed that high cTnT (p=0.0005), BNP (p=0.0001), 
      renin (p=0.0158), NOREPI (p=0.0094), old age (p=0.0390), low LVEF (p=0.0231) and 
      high New York Heart Association (NYHA) class (p=0.0006) were predictors of death 
      from or rehospitalization for CHF. By multivariate analysis including BNP, 
      NOREPI, age, LVEF and NYHA class, high cTnT and renin remained as significant 
      predictors. CONCLUSIONS: Patients with ongoing myocardial injury and high cTnT 
      had associated findings consistent with activation of the sympathetic system, 
      synthesis of cardiac fibrosis, inflammation and metabolic abnormalities. By 
      multivariate analysis, high cTnT and renin remained significant predictors of 
      death or rehospitalization.
FAU - Nishio, Yukiko
AU  - Nishio Y
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Sato, Yukihito
AU  - Sato Y
FAU - Taniguchi, Ryoji
AU  - Taniguchi R
FAU - Shizuta, Satoshi
AU  - Shizuta S
FAU - Doi, Takahiro
AU  - Doi T
FAU - Morimoto, Takeshi
AU  - Morimoto T
FAU - Kimura, Takeshi
AU  - Kimura T
FAU - Kita, Toru
AU  - Kita T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 0 (Troponin T)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 3.4.23.15 (Renin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Aged
MH  - Aging
MH  - Biomarkers/*blood
MH  - Female
MH  - Heart Failure/*blood/metabolism/mortality/therapy
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Myocardium/*metabolism
MH  - Natriuretic Peptide, Brain/blood
MH  - Norepinephrine/blood
MH  - Patient Readmission
MH  - Prognosis
MH  - Renin/blood
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Troponin T/*blood/metabolism
EDAT- 2007/04/26 09:00
MHDA- 2007/05/24 09:00
CRDT- 2007/04/26 09:00
PHST- 2007/04/26 09:00 [pubmed]
PHST- 2007/05/24 09:00 [medline]
PHST- 2007/04/26 09:00 [entrez]
AID - JST.JSTAGE/circj/71.631 [pii]
AID - 10.1253/circj.71.631 [doi]
PST - ppublish
SO  - Circ J. 2007 May;71(5):631-5. doi: 10.1253/circj.71.631.