PMID- 17456996
OWN - NLM
STAT- MEDLINE
DCOM- 20070523
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 71
IP  - 5
DP  - 2007 May
TI  - Coronary artery aneurysm induced by Kawasaki disease in children show features 
      typical senescence.
PG  - 709-15
AB  - BACKGROUND: Kawasaki disease (KD) causes coronary artery disease (CAD) in 
      children. In addition, a history of KD is suspected to be a risk factor for the 
      development of atherosclerotic heart disease in the future. Histological 
      senescence changes are a common denominator in atherosclerotic lesions in adults, 
      so the present study investigated whether histological senescence changes had 
      already occurred in KD aneurysm. METHODS AND RESULTS: KD coronary aneurysms and 
      internal mammary arteries retrieved from 5 children with KD (3, 4, 5, 6, and 11 
      years old, respectively) who underwent coronary artery bypass grafting, as well 
      as giant coronary aneurysm size-reducing operations, were analyzed. 
      Senescence-associated strong beta-galactosidase activity was observed in KD 
      aneurysms, but not in the internal mammary arteries. An immunohistochemical 
      analysis of the KD aneurysm using anti-CD31, anti-endothelial nitric oxide 
      synthetase (eNOS), anti-vascular adhesion molecule-1 (VCAM-1), and anti-monocyte 
      chemoattractant protein-1 (MCP-1) showed vascular endothelium CD31 staining, 
      decreased staining of eNOS and strong staining of MCP-1 and VCAM-1. cDNA 
      microarray gene expression profiling revealed increased MCP-1 expression in the 
      KD aneurysm, a finding confirmed by quantitative polymerase chain reaction. 
      CONCLUSIONS: Histological features of senescence and active remodeling gene 
      expression show that the KD aneurysm is not a silent vasculitis terminal. The 
      future fate of KD aneurysms, including atherosclerosis, should be monitored 
      carefully.
FAU - Fukazawa, Ryuji
AU  - Fukazawa R
AD  - Department of Pediatrics, Cardiovascular Surgery, Nippon Medical School, Tokyo, 
      Japan. oraora@nms.ac.jp
FAU - Ikegam, Ei
AU  - Ikegam E
FAU - Watanabe, Miki
AU  - Watanabe M
FAU - Hajikano, Miharu
AU  - Hajikano M
FAU - Kamisago, Mitsuhiro
AU  - Kamisago M
FAU - Katsube, Yasuhiro
AU  - Katsube Y
FAU - Yamauchi, Hitoshi
AU  - Yamauchi H
FAU - Ochi, Masami
AU  - Ochi M
FAU - Ogawa, Shunichi
AU  - Ogawa S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
MH  - Aging/*metabolism
MH  - Cardiac Surgical Procedures
MH  - Chemokine CCL2/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Coronary Aneurysm/*etiology/genetics/metabolism/*pathology
MH  - Coronary Artery Bypass
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*complications/genetics/metabolism/*pathology
MH  - Oligonucleotide Array Sequence Analysis
MH  - Polymerase Chain Reaction
MH  - Staining and Labeling
MH  - beta-Galactosidase/metabolism
EDAT- 2007/04/26 09:00
MHDA- 2007/05/24 09:00
CRDT- 2007/04/26 09:00
PHST- 2007/04/26 09:00 [pubmed]
PHST- 2007/05/24 09:00 [medline]
PHST- 2007/04/26 09:00 [entrez]
AID - JST.JSTAGE/circj/71.709 [pii]
AID - 10.1253/circj.71.709 [doi]
PST - ppublish
SO  - Circ J. 2007 May;71(5):709-15. doi: 10.1253/circj.71.709.