PMID- 17459243
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20191210
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 43
IP  - 2
DP  - 2007 Feb
TI  - [Experimental study a new device of scleral flap stent on filtration surgery in 
      normal sheep].
PG  - 129-33
AB  - OBJECTIVE: To test the effectiveness and safety of a filtering drainage device, a 
      scleral flap stent (SFS) made of poly methyl methacrylate (PMMA) in 
      trabeculectomy (or filtering drainage-plasty) in sheep. METHODS: 32 of normal 
      sheep were used. Trabeculectomy was performed in both eyes and the filtering 
      drainage device, a SFS was randomly implanted under the scleral flap in one eye. 
      After the surgery, the intraocular pressure (IOP) was measured by Schiotz 
      tonometer; The filtering blebs and its histopathology was examined by a slit 
      lamp, an ultrasound biomicroscope (UBM), and electronmicroscopy. RESULTS: The IOP 
      in eyes with trabeculectomy plus SFS was statistically significant (P < 0.001) 
      lower than that in eyes with trabeculectomy along at one month (11.38 +/- 1.20) 
      mm Hg vs (14.05 +/- 0.93) mm Hg and at three months (11.95 +/- 1.18) mm Hg vs 
      (15.2 +/- 1.09 mm Hg). Compared to the pre-operation, no difference in IOP was 
      found at one month in eyes with trabeculectomy along (16.04 +/- 1.02) mm Hg vs 
      (14.05 +/- 0.93) mm Hg. The filtering bleb was lasted more than 3 months in eyes 
      with trabeculectomy plus SFS while existed only one month in eyes with 
      trabeculectomy along by both slit lamp and UBM examination. The fibroblastic 
      proliferation of filtering pathway and scar formation was found at one months 
      post-operation in eyes with trabeculectomy along, however, the fibroblastic 
      proliferation and the scar formation were found at three months and at six months 
      after surgery in eyes with trabeculectomy plus SFS, respectively, by a light and 
      electronmicroscopy examination. Tissue compliance was good and no elimination 
      occurred. No toxic or adverse effects were observed in the following year 
      post-operatively. CONCLUSION: SFS is a safe and effective newly designed 
      filtering drainage device in lowering IOP when performed together with 
      trabeculectomy.
FAU - Zhang, Xu-Xiang
AU  - Zhang XX
AD  - Department of Ophthalmology, The Tianjin Medical University General Hospital, 
      Tianjin 300052, China. zhang_xuxiang@hotmail.com
FAU - He, Zhong-Jiang
AU  - He ZJ
FAU - Yan, Yi-Ming
AU  - Yan YM
FAU - Lin, Jin-Yong
AU  - Lin JY
FAU - Xu, Shen
AU  - Xu S
FAU - Gao, Jian-Min
AU  - Gao JM
FAU - Xu, Ying-Hai
AU  - Xu YH
FAU - Yan, Hua
AU  - Yan H
LA  - chi
PT  - Evaluation Study
PT  - Journal Article
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
SB  - IM
MH  - Animals
MH  - *Filtering Surgery
MH  - Sclera/*transplantation
MH  - Sheep
MH  - Surgical Flaps
MH  - *Trabeculectomy
EDAT- 2007/04/27 09:00
MHDA- 2010/11/05 06:00
CRDT- 2007/04/27 09:00
PHST- 2007/04/27 09:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
PHST- 2007/04/27 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2007 Feb;43(2):129-33.