PMID- 17459415
OWN - NLM
STAT- MEDLINE
DCOM- 20080411
LR  - 20080115
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 265
IP  - 1-2
DP  - 2008 Feb 15
TI  - Neurotrophic cross-talk between the nervous and immune systems: relevance for 
      repair strategies in multiple sclerosis?
PG  - 93-6
AB  - Autoreactive T and B cells are regular components of the healthy immune system. 
      It has been proposed that some of these cells might have a protective function. 
      Recent studies support this notion by demonstrating that a) myelin-autoreactive T 
      cells show neuroprotective effects in vivo, and b) activated antigen-specific 
      human T cells and other immune cells produce bioactive brain-derived neurotrophic 
      factor (BDNF) and other neurotrophic factors in vitro. Furthermore, neurotrophic 
      factors are expressed in different types of inflammatory cells in brain lesions 
      of patients with acute disseminated leukoencephalopathy or multiple sclerosis. It 
      seems plausible that the immune cell-mediated import of neurotrophic factors into 
      the central nervous system has functional consequences, with obvious implications 
      for the therapy of multiple sclerosis and other neuroimmunological diseases.
FAU - Hohlfeld, Reinhard
AU  - Hohlfeld R
AD  - Institute of Clinical Neuroimmunology, Campus Grosshadern, Ludwig-Maximilians 
      University, Marchioninistr, 15, D-81366 Munich, Germany. hohlfeld@neuro.mpg.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070424
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immune System/*physiopathology
MH  - Multiple Sclerosis/*metabolism/physiopathology/therapy
MH  - Nerve Growth Factors/*physiology
MH  - Nervous System/*physiopathology
RF  - 20
EDAT- 2007/04/27 09:00
MHDA- 2008/04/12 09:00
CRDT- 2007/04/27 09:00
PHST- 2007/02/09 00:00 [received]
PHST- 2007/03/16 00:00 [accepted]
PHST- 2007/04/27 09:00 [pubmed]
PHST- 2008/04/12 09:00 [medline]
PHST- 2007/04/27 09:00 [entrez]
AID - S0022-510X(07)00214-6 [pii]
AID - 10.1016/j.jns.2007.03.012 [doi]
PST - ppublish
SO  - J Neurol Sci. 2008 Feb 15;265(1-2):93-6. doi: 10.1016/j.jns.2007.03.012. Epub 
      2007 Apr 24.