PMID- 17459471
OWN - NLM
STAT- MEDLINE
DCOM- 20070720
LR  - 20220310
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 41
IP  - 3
DP  - 2007 Jun
TI  - Temporal changes in the expression of some neurotrophins in spinal cord 
      transected adult rats.
PG  - 135-43
AB  - Functional recovery of neurons in the spinal cord after physical injury is 
      essentially abortive in clinical cases. As neurotrophins had been reported to be 
      responsible, at least partially, for the lesion-induced recovery of spinal cord, 
      it is not surprising that they have become the focus of numerous studies. Studies 
      on endogenous neurotrophins, especially the three more important ones, nerve 
      growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 
      (NT-3) in injured spinal cord might provide some important clues in clinical 
      treatment. Here we investigate the immunohistological expression of the above 
      three factors at lower thoracic levels of the spinal cord as well as changes in 
      the motor functions of the adult rat hindlimbs after cord transection. The 
      injured rats were allowed to survive 3, 7, 14 and 21 days post operation (dpo). 
      Flaccid paralysis was seen at 3 dpo following cord transection, however, hindlimb 
      function showed partial recovery from 7 dpo to 21 dpo. The numbers of NGF, BDNF 
      and NT-3 immunopositive neurons and their optical densities all increased in the 
      lesion-induced cord. The immuno-expression of NGF and BDNF peaked at 7 dpo, while 
      that of NT-3 peaked at 7 dpo and remained so at least up to 14 dpo. These results 
      suggested that neurotrophins might play essential roles in functional recovery of 
      after spinal cord injury, but the time points for the expression of the three 
      factors differed somewhat.
FAU - Li, Xiao-Li
AU  - Li XL
AD  - Institute of Neuroscience, Kunming Medical College, Kunming 650031, China.
FAU - Zhang, Wei
AU  - Zhang W
FAU - Zhou, Xue
AU  - Zhou X
FAU - Wang, Xu-Yang
AU  - Wang XY
FAU - Zhang, Hong-Tian
AU  - Zhang HT
FAU - Qin, Dan-Xia
AU  - Qin DX
FAU - Zhang, Han
AU  - Zhang H
FAU - Li, Qun
AU  - Li Q
FAU - Li, Min
AU  - Li M
FAU - Wang, Ting-Hua
AU  - Wang TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070424
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Female
MH  - Hindlimb/physiology
MH  - Immunohistochemistry
MH  - Intracellular Space/metabolism
MH  - Locomotion/physiology
MH  - Nerve Growth Factor/biosynthesis
MH  - Nerve Growth Factors/*biosynthesis
MH  - Neurotrophin 3/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/*metabolism
MH  - Survival Analysis
MH  - Time Factors
EDAT- 2007/04/27 09:00
MHDA- 2007/07/21 09:00
CRDT- 2007/04/27 09:00
PHST- 2006/07/20 00:00 [received]
PHST- 2007/02/14 00:00 [revised]
PHST- 2007/02/15 00:00 [accepted]
PHST- 2007/04/27 09:00 [pubmed]
PHST- 2007/07/21 09:00 [medline]
PHST- 2007/04/27 09:00 [entrez]
AID - S0143-4179(07)00018-2 [pii]
AID - 10.1016/j.npep.2007.02.001 [doi]
PST - ppublish
SO  - Neuropeptides. 2007 Jun;41(3):135-43. doi: 10.1016/j.npep.2007.02.001. Epub 2007 
      Apr 24.