PMID- 17460163
OWN - NLM
STAT- MEDLINE
DCOM- 20070530
LR  - 20101118
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1100
DP  - 2007 Apr
TI  - Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of 
      Healthy Aging).
PG  - 21-45
AB  - The aim of the 5-year European Union (EU)-Integrated Project GEnetics of Healthy 
      Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing 
      Genomics Institute from China), is to identify genes involved in healthy aging 
      and longevity, which allow individuals to survive to advanced old age in good 
      cognitive and physical function and in the absence of major age-related diseases. 
      To achieve this aim a coherent, tightly integrated program of research that 
      unites demographers, geriatricians, geneticists, genetic epidemiologists, 
      molecular biologists, bioinfomaticians, and statisticians has been set up. The 
      working plan is to: (a) collect DNA and information on the health status from an 
      unprecedented number of long-lived 90+ sibpairs (n = 2650) and of younger 
      ethnically matched controls (n = 2650) from 11 European countries; (b) perform a 
      genome-wide linkage scannning in all the sibpairs (a total of 5300 individuals); 
      this investigation will be followed by linkage disequilibrium mapping (LD 
      mapping) of the candidate chromosomal regions; (c) study in cases (i.e., the 2650 
      probands of the sibpairs) and controls (2650 younger people), genomic regions 
      (chromosome 4, D4S1564, chromosome 11, 11.p15.5) which were identified in 
      previous studies as possible candidates to harbor longevity genes; (d) genotype 
      all recruited subjects for apoE polymorphisms; and (e) genotype all recruited 
      subjects for inherited as well as epigenetic variability of the mitochondrial DNA 
      (mtDNA). The genetic analysis will be performed by 9 high-throughput platforms, 
      within the framework of centralized databases for phenotypic, genetic, and mtDNA 
      data. Additional advanced approaches (bioinformatics, advanced statistics, 
      mathematical modeling, functional genomics and proteomics, molecular biology, 
      molecular genetics) are envisaged to identify the gene variant(s) of interest. 
      The experimental design will also allow (a) to identify gender-specific genes 
      involved in healthy aging and longevity in women and men stratified for ethnic 
      and geographic origin and apoE genotype; (b) to perform a longitudinal survival 
      study to assess the impact of the identified genetic loci on 90+ people 
      mortality; and (c) to develop mathematical and statistical models capable of 
      combining genetic data with demographic characteristics, health status, 
      socioeconomic factors, lifestyle habits.
FAU - Franceschi, Claudio
AU  - Franceschi C
AD  - C.I.G.-Interdepartmental Centre "L.Galvani," University of Bologna, Via S. 
      Giacomo 12, 40126 Bologna, Italy. claudio.franceschi@unibo.it
FAU - Bezrukov, Vladyslav
AU  - Bezrukov V
FAU - Blanche, Helene
AU  - Blanche H
FAU - Bolund, Lars
AU  - Bolund L
FAU - Christensen, Kaare
AU  - Christensen K
FAU - de Benedictis, Giovanna
AU  - de Benedictis G
FAU - Deiana, Luca
AU  - Deiana L
FAU - Gonos, Efsthatios
AU  - Gonos E
FAU - Hervonen, Antti
AU  - Hervonen A
FAU - Yang, Huanning
AU  - Yang H
FAU - Jeune, Bernard
AU  - Jeune B
FAU - Kirkwood, Tom B L
AU  - Kirkwood TB
FAU - Kristensen, Peter
AU  - Kristensen P
FAU - Leon, Alberta
AU  - Leon A
FAU - Pelicci, Pier Giuseppe
AU  - Pelicci PG
FAU - Peltonen, Leena
AU  - Peltonen L
FAU - Poulain, Michel
AU  - Poulain M
FAU - Rea, Irene Maeve
AU  - Rea IM
FAU - Remacle, Jose
AU  - Remacle J
FAU - Robine, Jean Marie
AU  - Robine JM
FAU - Schreiber, Stefan
AU  - Schreiber S
FAU - Sikora, Ewa
AU  - Sikora E
FAU - Slagboom, Pieternella Eline
AU  - Slagboom PE
FAU - Spazzafumo, Liana
AU  - Spazzafumo L
FAU - Stazi, Maria Antonietta
AU  - Stazi MA
FAU - Toussaint, Olivier
AU  - Toussaint O
FAU - Vaupel, James W
AU  - Vaupel JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*genetics
MH  - Animals
MH  - DNA, Mitochondrial/genetics
MH  - Europe
MH  - European Union
MH  - Genetic Linkage
MH  - Genome
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Middle Aged
MH  - Models, Biological
MH  - Models, Genetic
RF  - 66
EDAT- 2007/04/27 09:00
MHDA- 2007/05/31 09:00
CRDT- 2007/04/27 09:00
PHST- 2007/04/27 09:00 [pubmed]
PHST- 2007/05/31 09:00 [medline]
PHST- 2007/04/27 09:00 [entrez]
AID - 1100/1/21 [pii]
AID - 10.1196/annals.1395.003 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Apr;1100:21-45. doi: 10.1196/annals.1395.003.