PMID- 17460490
OWN - NLM
STAT- MEDLINE
DCOM- 20070501
LR  - 20220311
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 44
IP  - 5
DP  - 2007 May
TI  - Tissue transglutaminase antibodies are a useful serological marker for the 
      diagnosis of celiac disease in patients with Down syndrome.
PG  - 583-6
AB  - BACKGROUND: Celiac disease (CD) is overrepresented among patients with Down 
      syndrome (DS), who frequently lack any typical symptoms. Therefore, screening for 
      CD is recommended in this high-risk group. The aim of the study was to determine 
      the prevalence of CD in Arab children with DS and evaluate the contribution of 
      immunoglobulin (Ig) A and IgG anti-gliadin antibodies (AGA), IgA and IgG tissue 
      transglutaminase (TTG) antibodies, and IgA anti-endomysial antibodies (EMA) to 
      screen for CD in children with DS. PATIENTS AND METHODS: A total of 52 Arab 
      patients with DS and 52 healthy Arab control subjects were studied for CD using 
      various serological markers. Data on age, sex, weight, height, gastrointestinal 
      symptoms, and endocrine abnormalities were recorded. Human leukocyte antigen 
      (HLA) was studied in patients undergoing small intestinal biopsy. RESULTS: Five 
      patients with DS were IgA TTG-positive and only 1 patient with DS was IgG 
      TTG-positive. EMA was negative in all patients with DS. TTG (IgA and IgG) and EMA 
      were negative in all control children. IgA AGA was positive in 12 patients with 
      DS and 3 control subjects (P = 0.02), whereas IgG AGA was positive in 41 patients 
      with DS and 26 control subjects (P = 0.004). Only children testing positive for 
      TTG underwent upper endoscopy with duodenal biopsy. Two children with DS were 
      diagnosed with CD. Both patients were IgA TTG-positive. One was HLA DQ2-positive 
      and another was negative for HLA DQ2 and DQ8. CONCLUSIONS: CD is prevalent (3.8%) 
      in Arab patients with DS. Based on our cohort, IgA TTG is useful in diagnosing 
      patients with CD and DS.
FAU - Shamaly, Hussein
AU  - Shamaly H
AD  - Pediatric Gastroenterology and Nutrition, Meyer's Children Hospital, Haifa, 
      Israel.
FAU - Hartman, Corina
AU  - Hartman C
FAU - Pollack, Shimon
AU  - Pollack S
FAU - Hujerat, Mohammad
AU  - Hujerat M
FAU - Katz, Rina
AU  - Katz R
FAU - Gideoni, Osnat
AU  - Gideoni O
FAU - Shamir, Raanan
AU  - Shamir R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin A)
RN  - 9007-90-3 (Gliadin)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
MH  - Autoantibodies/*immunology
MH  - Biomarkers/blood
MH  - Celiac Disease/blood/*diagnosis/epidemiology/*immunology
MH  - Child
MH  - Comorbidity
MH  - Down Syndrome/epidemiology
MH  - Female
MH  - Gliadin/immunology
MH  - Humans
MH  - Immunoglobulin A/immunology
MH  - Male
MH  - Muscle Fibers, Skeletal/immunology
MH  - Prevalence
MH  - Transglutaminases/*blood
EDAT- 2007/04/27 09:00
MHDA- 2007/05/02 09:00
CRDT- 2007/04/27 09:00
PHST- 2007/04/27 09:00 [pubmed]
PHST- 2007/05/02 09:00 [medline]
PHST- 2007/04/27 09:00 [entrez]
AID - 00005176-200705000-00008 [pii]
AID - 10.1097/MPG.0b013e3180320679 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2007 May;44(5):583-6. doi: 
      10.1097/MPG.0b013e3180320679.