PMID- 17460725
OWN - NLM
STAT- MEDLINE
DCOM- 20071003
LR  - 20141120
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 8
IP  - 5
DP  - 2007 Jul
TI  - A promoter nucleotide variant of the dendritic cell-specific DCNP1 associates 
      with serum IgE levels specific for dust mite allergens among the Korean 
      asthmatics.
PG  - 369-78
AB  - Dendritic cells (DCs), the most abundant antigen-presenting cells in the lung, 
      have been drawing attention for their roles in specific allergic responses to 
      aeroallergens with support of Th lymphocytes, and in persistent inflammatory 
      changes in allergic asthma. To identify genetic factors that may be involved in 
      the asthma susceptibility and development of the disease phenotypes, we examined 
      association of DC-specific DCNP1 polymorphisms with the disease risk. The 
      case-control study revealed association of the nucleotide variants with serum 
      immunoglobulin E (IgE) levels specific for Dermatophagoides farinae (Der f 1) and 
      Dermatophagoides pteronyssinus (Der p 1), major aeroallergens of dust mites, 
      among subjects with asthma. In particular, the T-allele-carrying genotype 
      frequencies for one of the variants (c.-1289C>T) located in the promoter region 
      were found increased in the asthmatic group with low levels of the mite-specific 
      IgE (odds ratio (OR)=0.63 (0.48-0.83) for Der p 1). Results from functional 
      analyses indicated that the promoter variant would affect the gene expression by 
      modulating DNA-protein interaction. We propose that the genetic polymorphism of 
      DCNP1 may influence production of specific IgE by altering DC functions in the 
      mite allergen presenting and/or processing. The functional relevance of the 
      genetic variation would provide an important insight into the genetic basis of 
      allergic response to the mite antigens.
FAU - Kim, Y
AU  - Kim Y
AD  - The Center for Genome Science, National Institute of Health, Eunpyung-Gu, Seoul, 
      Korea. kimye@ngri.go.kr
FAU - Park, C-S
AU  - Park CS
FAU - Shin, H D
AU  - Shin HD
FAU - Choi, J-W
AU  - Choi JW
FAU - Cheong, H S
AU  - Cheong HS
FAU - Park, B L
AU  - Park BL
FAU - Choi, Y H
AU  - Choi YH
FAU - Jang, A S
AU  - Jang AS
FAU - Park, S W
AU  - Park SW
FAU - Lee, Y M
AU  - Lee YM
FAU - Lee, E J
AU  - Lee EJ
FAU - Park, S G
AU  - Park SG
FAU - Lee, J-Y
AU  - Lee JY
FAU - Lee, J-K
AU  - Lee JK
FAU - Han, B G
AU  - Han BG
FAU - Oh, B
AU  - Oh B
FAU - Kimm, K
AU  - Kimm K
LA  - eng
SI  - OMIM/609710
SI  - RefSeq/NM_130848
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070426
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (DCANP1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens
MH  - Antigen Presentation
MH  - Antigens, Dermatophagoides/*immunology
MH  - Asthma/*genetics/*immunology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Gene Expression
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
EDAT- 2007/04/27 09:00
MHDA- 2007/10/04 09:00
CRDT- 2007/04/27 09:00
PHST- 2007/04/27 09:00 [pubmed]
PHST- 2007/10/04 09:00 [medline]
PHST- 2007/04/27 09:00 [entrez]
AID - 6364394 [pii]
AID - 10.1038/sj.gene.6364394 [doi]
PST - ppublish
SO  - Genes Immun. 2007 Jul;8(5):369-78. doi: 10.1038/sj.gene.6364394. Epub 2007 Apr 
      26.