PMID- 1746211
OWN - NLM
STAT- MEDLINE
DCOM- 19920114
LR  - 20041117
IS  - 0587-2421 (Print)
IS  - 0587-2421 (Linking)
VI  - 22
IP  - 2
DP  - 1991 Mar-Apr
TI  - Human leukocyte antigen compatibility and failure to achieve a viable pregnancy 
      with assisted reproductive technology.
PG  - 103-7
AB  - Many couples fail to achieve a viable pregnancy with multiple attempts of 
      Assisted Reproductive Technology (ART). Immunologic rejection of the embryo may 
      be a factor in these couples. We evaluated shared human leukocyte antigen (HLA) 
      antigenicity in 10 couples who failed multiple ART cycles and compared them with 
      10 couples who achieved a viable pregnancy with their first ART attempt. Study 
      couples shared a statistically significant greater number of HLA antigens than 
      control couples. Leukocyte immunotherapy is discussed. We conclude that couples 
      who share multiple HLA antigens may have an immunologic basis for failing to 
      achieve a viable pregnancy with multiple ART cycles.
FAU - Weckstein, L N
AU  - Weckstein LN
AD  - Department of Obstetrics and Gynecology, University of California, Irvine.
FAU - Patrizio, P
AU  - Patrizio P
FAU - Balmaceda, J P
AU  - Balmaceda JP
FAU - Asch, R H
AU  - Asch RH
FAU - Branch, D W
AU  - Branch DW
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Acta Eur Fertil
JT  - Acta Europaea fertilitatis
JID - 1300660
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - *Embryo Transfer
MH  - Female
MH  - *Fertilization in Vitro
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Infertility/*immunology
MH  - Pregnancy
MH  - Treatment Outcome
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
PST - ppublish
SO  - Acta Eur Fertil. 1991 Mar-Apr;22(2):103-7.