PMID- 17462509
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 5
DP  - 2007 May
TI  - The genetic influence of the nonclassical MHC molecule HLA-G on multiple 
      sclerosis.
PG  - 422-5
AB  - Human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility 
      complex (MHC) molecule located at MHC complex at chromosome 6 and chiefly 
      attributed immunoregulatory and tolerogenic functions. HLA-G is upregulated at 
      sites of inflammation in multiple sclerosis (MS) and assumed to counterbalance 
      immune responses. Different functionally relevant genetic variants of HLA-G have 
      been described and shown to be statistically associated with human diseases such 
      as fetal loss or sarcoidosis. We investigated the influence of three different 
      variations in the HLA-G gene for disease susceptibility and course of MS (n = 
      698): (1) The -725 C/G exchange in the HLA-G promoter region, (2) HLA-G*0105N, a 
      deletion that results in an irregular stopcodon in exon 3, and (3) a 14 bp 
      insertion / deletion in the untranslated exon 8. None of these variations 
      significantly influenced the susceptibility to multiple sclerosis. No association 
      was seen with the age of onset of disease, disease severity or disease course. 
      Although HLA-G is assumed to play an important role in the immunoregulatory 
      processes of MS, our results do not support a role of genetic factors influencing 
      disease susceptibility of the disease course.
FAU - Kroner, Antje
AU  - Kroner A
AD  - Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of 
      Neurology, University of Wurzburg, Wurzburg, Germany.
FAU - Grimm, Alexander
AU  - Grimm A
FAU - Johannssen, Kirsten
AU  - Johannssen K
FAU - Maurer, Mathias
AU  - Maurer M
FAU - Wiendl, Heinz
AU  - Wiendl H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070215
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (5' Untranslated Regions)
RN  - 0 (Codon, Nonsense)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - 5' Untranslated Regions
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Codon, Nonsense
MH  - Exons
MH  - Female
MH  - Frameshift Mutation
MH  - Gene Deletion
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*genetics
MH  - Multiple Sclerosis, Chronic Progressive/genetics
MH  - Multiple Sclerosis, Relapsing-Remitting/genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
EDAT- 2007/04/28 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/04/28 09:00
PHST- 2006/11/03 00:00 [received]
PHST- 2007/01/07 00:00 [revised]
PHST- 2007/01/09 00:00 [accepted]
PHST- 2007/04/28 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/04/28 09:00 [entrez]
AID - S0198-8859(07)00024-9 [pii]
AID - 10.1016/j.humimm.2007.01.012 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 May;68(5):422-5. doi: 10.1016/j.humimm.2007.01.012. Epub 2007 
      Feb 15.