PMID- 17462513
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20071115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 5
DP  - 2007 May
TI  - Comparison distribution of HLA-B alleles in mexican patients with takayasu 
      arteritis and tuberculosis.
PG  - 449-53
AB  - A possible relationship between Takayasu arteritis (TA) and Tuberculosis (Tb) has 
      been suggested. Both diseases present similar chronic inflammatory lesions and 
      occasionally granulomas on the arterial walls. The genetic relationship between 
      these two diseases has not been explored before, however, both diseases have been 
      associated with human leukocyte antigen (HLA) alleles. Therefore, the aim of the 
      present study was to analyze the distribution of HLA-B alleles in TA (n = 40) and 
      Tb (n = 34) patients and healthy controls (72 exposed and 99 nonexposed). HLA-B 
      alleles were determined by reverse dot blot. The statistical methods used 
      included the Chi(2), and odds ratio (OR) with 95% confidence intervals. In spite 
      of the loose clinical relationship between TA and Tb, we did not detected any 
      genetic relationship between them when the HLA-B alleles were analyzed in these 
      groups of patients. On the contrary, we detected distinct specific HLA-B alleles 
      for each disease. TA was characterized by HLA-B39, -B44, and -B52, pulmonary Tb 
      by HL-B35 and extrapulmonary Tb by HLA-B39 and -B40. This preliminary study 
      suggests a difference in the distribution of HLA-B alleles in patients with TA 
      and Tb.
FAU - Soto, Maria Elena
AU  - Soto ME
AD  - Department of Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico City, Mexico.
FAU - Vargas-Alarcon, Gilberto
AU  - Vargas-Alarcon G
FAU - Cicero-Sabido, Raul
AU  - Cicero-Sabido R
FAU - Ramirez, Ernestina
AU  - Ramirez E
FAU - Alvarez-Leon, Edith
AU  - Alvarez-Leon E
FAU - Reyes, Pedro A
AU  - Reyes PA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070216
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - *Gene Frequency
MH  - HLA-B Antigens/*genetics
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Takayasu Arteritis/*genetics
MH  - Tuberculosis/*genetics
MH  - Tuberculosis, Pulmonary/genetics
EDAT- 2007/04/28 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/04/28 09:00
PHST- 2006/06/19 00:00 [received]
PHST- 2006/12/19 00:00 [revised]
PHST- 2007/01/08 00:00 [accepted]
PHST- 2007/04/28 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/04/28 09:00 [entrez]
AID - S0198-8859(07)00014-6 [pii]
AID - 10.1016/j.humimm.2007.01.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 May;68(5):449-53. doi: 10.1016/j.humimm.2007.01.004. Epub 2007 
      Feb 16.