PMID- 17462943
OWN - NLM
STAT- MEDLINE
DCOM- 20070725
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 118
IP  - 7
DP  - 2007 Jul
TI  - Short latency afferent inhibition is not impaired in mild cognitive impairment.
PG  - 1460-3
AB  - OBJECTIVE: To determine whether cortical cholinergic circuit impairment exists in 
      the mild cognitive impairment (MCI) brain. METHODS: Fifteen healthy elderly 
      controls (NC), 16 amnesic MCI subjects and 12 probable Alzheimer's disease (AD) 
      subjects were recruited. Conditioning stimuli were delivered at the right wrist 
      followed by test transcranial magnetic stimulation (TMS) of the left motor 
      cortex. The center of the linear contiguous segment of the coil was placed over a 
      point 5 cm lateral to the vertex on the interaural line. The interstimulus 
      intervals (ISIs) between the conditioning stimuli and the test stimuli were set 
      at 20, 40, 100, 200 and 600 ms. An inhibitory effect that occurred at ISIs as 
      short as 20 ms was defined as short-latency afferent inhibition (SAI). RESULTS: 
      SAI was significantly reduced in subjects with AD compared with NC, but it was 
      not reduced in subjects with MCI. CONCLUSIONS: A difference in cortical 
      excitability between subjects with AD and subjects with MCI could be captured by 
      an in vivo neurophysiological method. SIGNIFICANCE: The state of the 
      neurotransmitter systems, including the cortical cholinergic system, is thought 
      by some compensatory mechanisms to be kept at the normal level in subjects with 
      MCI.
FAU - Sakuma, Kenji
AU  - Sakuma K
AD  - Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, 
      Tottori University, 36-1 Nishicho, Yonago, Japan. 
      ksakuma@grape.med.tottori-u.ac.jp
FAU - Murakami, Takenobu
AU  - Murakami T
FAU - Nakashima, Kenji
AU  - Nakashima K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070425
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Afferent Pathways/*physiopathology
MH  - Aged
MH  - Alzheimer Disease/*physiopathology
MH  - Amnesia/physiopathology
MH  - Cognition Disorders/*physiopathology
MH  - Evoked Potentials, Motor/physiology
MH  - Evoked Potentials, Somatosensory/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Median Nerve/physiopathology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Parasympathetic Nervous System/physiopathology
EDAT- 2007/04/28 09:00
MHDA- 2007/07/26 09:00
CRDT- 2007/04/28 09:00
PHST- 2006/07/28 00:00 [received]
PHST- 2007/03/14 00:00 [revised]
PHST- 2007/03/17 00:00 [accepted]
PHST- 2007/04/28 09:00 [pubmed]
PHST- 2007/07/26 09:00 [medline]
PHST- 2007/04/28 09:00 [entrez]
AID - S1388-2457(07)00138-1 [pii]
AID - 10.1016/j.clinph.2007.03.018 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2007 Jul;118(7):1460-3. doi: 10.1016/j.clinph.2007.03.018. 
      Epub 2007 Apr 25.