PMID- 17464199
OWN - NLM
STAT- MEDLINE
DCOM- 20071226
LR  - 20240315
IS  - 1016-8478 (Print)
IS  - 1016-8478 (Linking)
VI  - 23
IP  - 2
DP  - 2007 Apr 30
TI  - TTF-1 expression in PACAP-expressing retinal ganglion cells.
PG  - 215-9
AB  - In mammals light input resets the central clock of the suprachiasmatic nucleus by 
      inducing secretion of pituitary adenylate cyclase-activating polypeptide (PACAP) 
      from retinal ganglion cells (RGCs). We previously showed that thyroid 
      transcription factor 1 (TTF-1), a homeodomain-containing transcription factor, 
      specifically regulates PACAP gene expression in the rat hypothalamus. In the 
      present study we examined the expression of TTF-1 in PACAP-synthesizing retinal 
      cells. Fluorescence in situ hybridization (FISH) showed that it is abundantly 
      expressed in RGCs of the superior region of the retina, but in only a small 
      subset of RGCs in the inferior region. Double FISH experiments revealed that 
      TTF-1 is exclusively expressed in PACAP-producing RGCs. These results suggest 
      that TTF-1 plays a regulatory role in PACAP-expressing retinal ganglion cells.
FAU - Son, Young June
AU  - Son YJ
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan 680-749, Korea.
FAU - Park, Jeong Woo
AU  - Park JW
FAU - Lee, Byung Ju
AU  - Lee BJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Nkx2-1 protein, rat)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Pituitary Adenylate Cyclase-Activating Polypeptide)
RN  - 0 (Thyroid Nuclear Factor 1)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation
MH  - Male
MH  - Nuclear Proteins/*physiology
MH  - Pituitary Adenylate Cyclase-Activating Polypeptide/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retinal Ganglion Cells/*metabolism
MH  - Thyroid Nuclear Factor 1
MH  - Transcription Factors/*physiology
EDAT- 2007/04/28 09:00
MHDA- 2007/12/27 09:00
CRDT- 2007/04/28 09:00
PHST- 2007/04/28 09:00 [pubmed]
PHST- 2007/12/27 09:00 [medline]
PHST- 2007/04/28 09:00 [entrez]
AID - S1016-8478(23)07376-4 [pii]
PST - ppublish
SO  - Mol Cells. 2007 Apr 30;23(2):215-9.