PMID- 17465227
OWN - NLM
STAT- MEDLINE
DCOM- 20070510
LR  - 20181201
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 27
IP  - 2
DP  - 2007 Mar-Apr
TI  - The prognostic significance of human epidermal growth factor receptor 
      correlations in squamous cell cervical carcinoma.
PG  - 959-63
AB  - The aim of this study was to investigate the expression and prognostic influence 
      of HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3) and HER4 (cerb-B4) in squamous 
      cell cervical carcinomas (SCC) and the importance of receptor correlations. 
      PATIENTS AND METHODS: 78 SCC were stained immunohistochemically for HER1-HER4. 
      HER2 gene amplification was determined using fluorescence in situ hybridization 
      (FISH). Parametric correlations were performed between the four receptors and 
      tumor characteristics. Overall survival was evaluated by uni- and multivariate 
      analyses. RESULTS: Overexpression was found in 63% of SCC for HER1, in 21.8% for 
      HER2, in 74.4% for HER3 and in 79.5% for HER4. Correlations were observed between 
      HER1 and HER4 (p = 0.019). Survival analyses revealed a significant association 
      of HER1 overexpression with favorable outcome (p = 0.016), while overexpression 
      of HER2 and HER3 was associated with poor prognosis (p = 0.006; p = 0.05, 
      respectively). HER1 remained significant in multivariate analysis. CONCLUSION: 
      These data suggest that the prognostic relevance of the different HER receptors 
      is influenced by the balance between the various receptors, especially of HER4.
FAU - Fuchs, I
AU  - Fuchs I
AD  - Department of Gynecology, Charite C. Virchow, Augustenburger Platz 1, 13353 
      Berlin, Germany. ilka.fuchs@charite.de
FAU - Vorsteher, N
AU  - Vorsteher N
FAU - Buhler, H
AU  - Buhler H
FAU - Evers, K
AU  - Evers K
FAU - Sehouli, J
AU  - Sehouli J
FAU - Schaller, G
AU  - Schaller G
FAU - Kummel, S
AU  - Kummel S
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*enzymology/genetics/pathology/therapy
MH  - ErbB Receptors/*biosynthesis/genetics
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Rate
MH  - Uterine Cervical Neoplasms/*enzymology/genetics/pathology/therapy
EDAT- 2007/05/01 09:00
MHDA- 2007/05/11 09:00
CRDT- 2007/05/01 09:00
PHST- 2007/05/01 09:00 [pubmed]
PHST- 2007/05/11 09:00 [medline]
PHST- 2007/05/01 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2007 Mar-Apr;27(2):959-63.