PMID- 17465986
OWN - NLM
STAT- MEDLINE
DCOM- 20070817
LR  - 20151119
IS  - 0803-5253 (Print)
IS  - 0803-5253 (Linking)
VI  - 96
IP  - 6
DP  - 2007 Jun
TI  - Inflammation at birth and the insulin-like growth factor system in very preterm 
      infants.
PG  - 830-6
AB  - BACKGROUND: Foetal inflammation is associated with an increased risk of brain 
      damage in preterm infants whereas IGF-I is essential for cerebral development and 
      exhibits anti-apoptotic properties. AIM: To assess levels of IGF-I and IGF 
      binding proteins at very preterm birth and to evaluate their relationship with 
      foetal pro-inflammation and cerebral damage. METHODS: Levels of IGF-I, IGF 
      binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in 
      cord blood and neonatal blood at 72 h after delivery were analysed in relation to 
      levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn 
      infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed 
      separately according to birth weight for GA. RESULTS: In cord blood of infants 
      appropriate for gestational age (AGA) higher levels of IL-6 and IL-8 were 
      associated with lower IGF-I (r =-0.38, p = 0.008 and r =-0.36, p = 0.014). Higher 
      levels of IL-6, IL-8 and TNF-alpha were associated with both higher levels of 
      lpIGFBP-1 (r = 0.54, p < 0.001, r = 0.50, p < 0.001 and r = 0.13, p = 0.012, 
      respectively) and hpIGFBP-1 (r = 0.55, p < 0.001, r = 0.45, p = 0.002 and r = 
      0.32, p = 0.026, respectively). Infants with intraventricular haemorrhage grade 
      III (n = 5) had higher levels of lp/hpIGFBP-1 in cord blood (p = 0.001 and 0.002, 
      respectively). CONCLUSION: Pro-inflammation at birth is associated with changes 
      in the IGF-system. This may be of importance for development of brain damage in 
      preterm infants.
FAU - Hansen-Pupp, I
AU  - Hansen-Pupp I
AD  - Institution of Clinical Sciences and Department of Pediatrics, Lund University, 
      Lund, Sweden. ingrid.pupp@skane.se
FAU - Hellstrom-Westas, L
AU  - Hellstrom-Westas L
FAU - Cilio, C M
AU  - Cilio CM
FAU - Andersson, S
AU  - Andersson S
FAU - Fellman, V
AU  - Fellman V
FAU - Ley, D
AU  - Ley D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070427
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Biomarkers/blood
MH  - Brain/enzymology/immunology
MH  - Brain Injuries/*blood
MH  - Fetal Blood/chemistry
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Small for Gestational Age/*blood
MH  - Inflammation/*blood/diagnosis
MH  - Insulin-Like Growth Factor Binding Protein 1/blood
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/analysis
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Linear Models
MH  - Prospective Studies
EDAT- 2007/05/01 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/05/01 09:00
PHST- 2007/05/01 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/05/01 09:00 [entrez]
AID - APA276 [pii]
AID - 10.1111/j.1651-2227.2007.00276.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2007 Jun;96(6):830-6. doi: 10.1111/j.1651-2227.2007.00276.x. Epub 
      2007 Apr 27.