PMID- 17467829
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20151119
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 126
IP  - 3
DP  - 2008 Jun 6
TI  - Expression of monocyte chemoattractant protein-1 in idiopathic dilated 
      cardiomyopathy.
PG  - 427-9
AB  - Immunological factors have been involved in the pathogenesis of dilated 
      cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main 
      factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 
      (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We 
      examined whether MCP-1 was expressed in the myocardium of DCM patients and 
      whether the expression level was correlated with the degree of impairment of 
      cardiac function. The expression of MCP-1 in the myocardium was determined by 
      immunohistochemistry in endomyocardial biopsy samples from 13 patients. The 
      expression of MCP-1 was found in all myocardial samples from DCM patients but not 
      in those from control subjects. Positive staining for MCP-1 was distinct in 
      cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis 
      revealed that the expression of MCP-1 was inversely correlated with left 
      ventricular ejection fraction. In conclusion, the expression level of MCP-1 in 
      the myocardium was correlated with the degree of impairment of cardiac function 
      in patients with DCM.
FAU - Kobayashi, Makoto
AU  - Kobayashi M
FAU - Nakamura, Kazufumi
AU  - Nakamura K
FAU - Kusano, Kengo Fukushima
AU  - Kusano KF
FAU - Nakamura, Yoichi
AU  - Nakamura Y
FAU - Ohta-Ogo, Keiko
AU  - Ohta-Ogo K
FAU - Nagase, Satoshi
AU  - Nagase S
FAU - Sakuragi, Satoru
AU  - Sakuragi S
FAU - Ohe, Tohru
AU  - Ohe T
LA  - eng
PT  - Letter
DEP - 20070430
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis
MH  - Biopsy, Needle
MH  - Cardiomyopathy, Dilated/*mortality/*pathology/physiopathology
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*metabolism
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Function Tests
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Probability
MH  - RNA, Messenger/analysis
MH  - Reference Values
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Survival Rate
EDAT- 2007/05/01 09:00
MHDA- 2008/07/30 09:00
CRDT- 2007/05/01 09:00
PHST- 2006/12/17 00:00 [received]
PHST- 2007/01/03 00:00 [accepted]
PHST- 2007/05/01 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2007/05/01 09:00 [entrez]
AID - S0167-5273(07)00584-0 [pii]
AID - 10.1016/j.ijcard.2007.01.109 [doi]
PST - ppublish
SO  - Int J Cardiol. 2008 Jun 6;126(3):427-9. doi: 10.1016/j.ijcard.2007.01.109. Epub 
      2007 Apr 30.