PMID- 17468440
OWN - NLM
STAT- MEDLINE
DCOM- 20071109
LR  - 20221207
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 13
IP  - 7
DP  - 2007 Aug
TI  - Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with 
      long spinal cord lesions.
PG  - 850-5
AB  - Multiple sclerosis (MS) in Asian populations is often characterized by the 
      selective involvement of the optic nerve (ON) and spinal cord (SP) (OSMS) in 
      contrast to classic MS (CMS), where frequent lesions are observed in the 
      cerebrum, cerebellum or brainstem. In Western countries, inflammatory 
      demyelinating disease preferentially involving the ON and SP is called 
      neuromyelitis optica (NMO). Recently, Lennon et al. discovered that NMO-IgG, 
      shown to bind to aquaporin 4 (AQP4), could be a specific marker of NMO and also 
      of Japanese OSMS whose clinical features were identical to NMO having long spinal 
      cord lesions extending over three vertebral segments (LCL). To examine this 
      antibody in larger populations of Japanese OSMS patients in order to know its 
      epidemiological and clinical spectra, we established an immunohistochemical 
      detection system for the anti-AQP4 antibody (AQP4-Ab) using the AQP4-transfected 
      human embryonic kidney cell line (HEK-293) and confirmed AQP4-Ab positivity 
      together with the immunohistochemical staining pattern of NMO-IgG in 
      approximately 60% of Japanese OSMS patients with LCL. Patients with OSMS without 
      LCL and those with CMS were negative for this antibody. Our results accorded with 
      those of Lennon et al. suggest that Japanese OSMS with LCL may have an underlying 
      pathogenesis in common with NMO.
FAU - Tanaka, K
AU  - Tanaka K
AD  - Department of Neurology, Brain Research Institute, Niigata University, Niigata 
      Japan. keiko@bri.niigata
FAU - Tani, T
AU  - Tani T
FAU - Tanaka, M
AU  - Tanaka M
FAU - Saida, T
AU  - Saida T
FAU - Idezuka, J
AU  - Idezuka J
FAU - Yamazaki, M
AU  - Yamazaki M
FAU - Tsujita, M
AU  - Tsujita M
FAU - Nakada, T
AU  - Nakada T
FAU - Sakimura, K
AU  - Sakimura K
FAU - Nishizawa, M
AU  - Nishizawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070427
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (AQP4 protein, human)
RN  - 0 (Aquaporin 4)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Aquaporin 4/genetics/*immunology
MH  - Asian People
MH  - Autoantibodies/*blood
MH  - Biomarkers/*blood
MH  - Cell Line
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Immunohistochemistry
MH  - Japan/epidemiology
MH  - Kidney/cytology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/epidemiology/*immunology/pathology
MH  - Neuromyelitis Optica/epidemiology/*immunology/pathology
MH  - Seroepidemiologic Studies
MH  - Spinal Cord/pathology
MH  - Transfection
EDAT- 2007/05/01 09:00
MHDA- 2007/11/10 09:00
CRDT- 2007/05/01 09:00
PHST- 2007/05/01 09:00 [pubmed]
PHST- 2007/11/10 09:00 [medline]
PHST- 2007/05/01 09:00 [entrez]
AID - 1352458507076976 [pii]
AID - 10.1177/1352458507076976 [doi]
PST - ppublish
SO  - Mult Scler. 2007 Aug;13(7):850-5. doi: 10.1177/1352458507076976. Epub 2007 Apr 
      27.