PMID- 17470388
OWN - NLM
STAT- MEDLINE
DCOM- 20071126
LR  - 20151119
IS  - 0944-7113 (Print)
IS  - 0944-7113 (Linking)
VI  - 14
IP  - 10
DP  - 2007 Oct
TI  - Protective action of honokiol, administered orally, against oxidative stress in 
      brain of mice challenged with NMDA.
PG  - 696-700
AB  - Neuroprotective effect of honokiol (HK), orally administered, on oxidative damage 
      in the brain of mice challenged with N-methyl-d-aspartic acid (NMDA) was 
      examined. HK (1-100 mg/kg) was administered to Institute of Cancer Research (ICR) 
      male mice through a gavage for 3 days consecutively, and on the third day, NMDA 
      (150 mg/kg) was intraperitoneally (i.p.) administered. Administration of NMDA, 
      causing a lethality of approximately 60%, resulted in a significant decrease of 
      total glutathione (GSH) level and increase of thiobarbituric acid-reactive 
      substances (TBARS) value in brain tissue. Meanwhile, oral administration of HK (> 
      or = 3 mg/kg) for 3 days reduced the lethality (60%) in NMDA-treated group to 10% 
      level, and alleviated the behavioral signs of NMDA neurotoxicity. Moreover, HK 
      pretreatment restored the levels of total GSH and TBARS in the brain tissue to 
      control levels (p<0.01). Additionally, GSH peroxidase activity in cytosolic 
      portion of brain homogenate was also restored significantly (p<0.01), whereas GSH 
      reductase activity was not. Separately, compared to vehicle-treated control, no 
      significant changes in body and brain weight were observed in mice administered 
      with HK. Based on these results, oral intake of HK is suggested to prevent 
      oxidative stress in the brain of mice.
FAU - Cui, H S
AU  - Cui HS
AD  - College of Pharmacy, Chungnam National University, Gung-Dong 220, Yuseong-Gu, 
      Taejon 305-764, Korea.
FAU - Huang, L S
AU  - Huang LS
FAU - Sok, D-E
AU  - Sok DE
FAU - Shin, J
AU  - Shin J
FAU - Kwon, B-M
AU  - Kwon BM
FAU - Youn, U J
AU  - Youn UJ
FAU - Bae, K
AU  - Bae K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070430
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Lignans)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - 11513CCO0N (honokiol)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Biphenyl Compounds/administration & dosage/*pharmacology/therapeutic use
MH  - Brain/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraperitoneal
MH  - Lignans/administration & dosage/*pharmacology/therapeutic use
MH  - *Magnolia
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - N-Methylaspartate
MH  - Neuroprotective Agents/administration & dosage/*pharmacology/therapeutic use
MH  - Oxidative Stress/*drug effects
MH  - *Phytotherapy
MH  - Plant Bark
MH  - Plant Extracts/administration & dosage/pharmacology/therapeutic use
EDAT- 2007/05/02 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/05/02 09:00
PHST- 2006/03/06 00:00 [received]
PHST- 2006/07/11 00:00 [accepted]
PHST- 2007/05/02 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/05/02 09:00 [entrez]
AID - S0944-7113(07)00043-8 [pii]
AID - 10.1016/j.phymed.2007.03.005 [doi]
PST - ppublish
SO  - Phytomedicine. 2007 Oct;14(10):696-700. doi: 10.1016/j.phymed.2007.03.005. Epub 
      2007 Apr 30.