PMID- 17470625
OWN - NLM
STAT- MEDLINE
DCOM- 20070719
LR  - 20130523
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 29
IP  - 5
DP  - 2007 May
TI  - Light chain deposition disease involving the airways: diagnosis by fibreoptic 
      bronchoscopy.
PG  - 1057-60
AB  - Light chain deposition disease (LCDD) infrequently affects the lungs and usually 
      causes damage to the parenchyma, while bronchial involvement appears to be very 
      rare. The present authors report the case of a 64-yr-old female with LCDD 
      characterised by asymptomatic airway involvement. Ten months after excision of a 
      poorly differentiated vaginal carcinoma, a routine chest computed tomography (CT) 
      scan revealed two lung cysts, several bilateral nodules and diffuse bronchial 
      thickening. Pulmonary function tests were normal. Fibreoptic bronchoscopy showed 
      marked diffuse mucosal thickening with highly conspicuous vascular plexuses. 
      Nonamyloidal deposits were found in the bronchial wall, but no definite diagnosis 
      could be proposed. On follow-up, the patient was still asymptomatic and the CT 
      scan and endoscopic appearance remained unchanged. The final diagnosis of kappa 
      LCDD was established 18 months later by another series of bronchial biopsies with 
      frozen samples. Interestingly, electron microscopy showed dense granular deposits 
      associated with nonamyloidal fibrils. An increased number of lung cysts were 
      observed 32 months after identification of bronchial abnormalities, confirming 
      the progressive nature of the disease. No extrapulmonary deposits or 
      immunoproliferative disorder were found. In conclusion, light chain deposition 
      disease, which may remain latent for several years, can entirely involve large 
      airways and may be diagnosed by bronchial biopsy.
FAU - Colombat, M
AU  - Colombat M
AD  - Service d'Anatomie Pathologique, Universite Pierre et Marie Curie, Paris, France. 
      colombatm@yahoo.fr
FAU - Gounant, V
AU  - Gounant V
FAU - Mal, H
AU  - Mal H
FAU - Callard, P
AU  - Callard P
FAU - Milleron, B
AU  - Milleron B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - *Bronchoscopy
MH  - Diagnosis, Differential
MH  - Female
MH  - Fiber Optic Technology
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Middle Aged
MH  - Respiratory Mucosa/pathology
MH  - Respiratory Tract Diseases/*diagnosis/pathology
EDAT- 2007/05/02 09:00
MHDA- 2007/07/20 09:00
CRDT- 2007/05/02 09:00
PHST- 2007/05/02 09:00 [pubmed]
PHST- 2007/07/20 09:00 [medline]
PHST- 2007/05/02 09:00 [entrez]
AID - 29/5/1057 [pii]
AID - 10.1183/09031936.00134406 [doi]
PST - ppublish
SO  - Eur Respir J. 2007 May;29(5):1057-60. doi: 10.1183/09031936.00134406.