PMID- 17472029
OWN - NLM
STAT- MEDLINE
DCOM- 20070606
LR  - 20220318
IS  - 0803-7051 (Print)
IS  - 0803-7051 (Linking)
VI  - 15
IP  - 6
DP  - 2006
TI  - Early left ventricular gene expression profile in response to increase in blood 
      pressure.
PG  - 375-83
AB  - The heart adapts to increased pressure overload by hypertrophic growth of 
      terminally differentiated cardiomyocytes. At the genetic level, the hypertrophic 
      response is characterized by the reprogramming of gene expression, i.e. 
      upregulation of immediate early genes, natriuretic peptide genes and genes 
      encoding structural proteins. In the present study, we characterized the early 
      changes in gene expression with cDNA expression arrays in response to increase in 
      blood pressure produced by arginine8-vasopressin infusion (0.05 microg/kg/min, 
      i.v.) for 30 min and 4 h in conscious normotensive rats. Expression profiling 
      revealed differential expression of 14 genes in the left ventricle, and several 
      novel factors of immediate early genetic response to pressure overload were 
      identified, such as growth arrest and DNA damage inducible protein 45 
      (GADD45alpha), epidermal fatty acid-binding protein (E-FABP) and Bcl-X. 
      Administration of angiotensin II (Ang II) for 6 h by osmotic minipumps also 
      increased left ventricular GADD45alpha, E-FABP and Bcl-X gene expression. 
      Furthermore, the induction of GADD45alpha and Bcl-X gene expression by Ang II was 
      blocked by angiotensin II type 1 receptor antagonist losartan. In summary, our 
      analysis provided new insights into the pathogenesis of pressure overload-induced 
      hypertrophy by suggesting the existence of novel regulators of the immediate 
      early gene expression program.
FAU - Rysa, Jaana
AU  - Rysa J
AD  - Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, 
      Finland.
FAU - Aro, Jani
AU  - Aro J
FAU - Ruskoaho, Heikki
AU  - Ruskoaho H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Blood Press
JT  - Blood pressure
JID - 9301454
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Bcl2l1 protein, rat)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Egr1 protein, rat)
RN  - 0 (Eye Proteins)
RN  - 0 (Fabp5 protein, rat)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Gadd45a protein, rat)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (RNA, Messenger)
RN  - 0 (bcl-X Protein)
RN  - 11128-99-7 (Angiotensin II)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Acute Disease
MH  - Angiotensin II/toxicity
MH  - Angiotensin II Type 1 Receptor Blockers/pharmacology/therapeutic use
MH  - Animals
MH  - Antihypertensive Agents/pharmacology/therapeutic use
MH  - Arginine Vasopressin/pharmacology/*toxicity
MH  - *Blood Pressure/drug effects
MH  - Cell Cycle Proteins/biosynthesis/genetics
MH  - Chronic Disease
MH  - Consciousness
MH  - DNA, Complementary/genetics
MH  - Early Growth Response Protein 1/biosynthesis/genetics
MH  - Eye Proteins/biosynthesis/genetics
MH  - Fatty Acid-Binding Proteins/biosynthesis/genetics
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/drug effects/*physiology
MH  - HSP70 Heat-Shock Proteins/biosynthesis/genetics
MH  - Heart Ventricles/*metabolism
MH  - Hypertension/chemically induced/drug therapy/*genetics/physiopathology
MH  - Losartan/pharmacology/therapeutic use
MH  - Male
MH  - Nerve Growth Factor/biosynthesis/genetics
MH  - Nerve Tissue Proteins/biosynthesis/genetics
MH  - Nuclear Proteins/biosynthesis/genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - Plasminogen Activator Inhibitor 1/biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - bcl-X Protein/*biosynthesis/genetics
EDAT- 2007/05/03 09:00
MHDA- 2007/06/07 09:00
CRDT- 2007/05/03 09:00
PHST- 2007/05/03 09:00 [pubmed]
PHST- 2007/06/07 09:00 [medline]
PHST- 2007/05/03 09:00 [entrez]
AID - 10.1080/08037050601037851 [doi]
PST - ppublish
SO  - Blood Press. 2006;15(6):375-83. doi: 10.1080/08037050601037851.