PMID- 17473839
OWN - NLM
STAT- MEDLINE
DCOM- 20080423
LR  - 20191210
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 33
IP  - 3
DP  - 2008 Feb
TI  - Gene x environment effects: stress and memory dysfunctions caused by stress and 
      gonadal factor irregularities during puberty in control and TGF-alpha hypomorphic 
      mice.
PG  - 557-65
AB  - The maturation of many neural functions occurs during puberty. An abnormal 
      development of these processes, in the context of genetic vulnerability, may 
      result in sex- and age-dependent penetrance of neuropsychiatric disorders. 
      Reduced transforming growth factors-alpha (TGF-alpha) expression in Waved-1 
      (Wa-1) mice impairs the stress response and fear memory in adult males, but are 
      absent or far less prominent in adult females and in pubertal males. Gonadectomy 
      around the onset of puberty, when the mutant anatomical and behavioral phenotypes 
      are undetectable, results in significant gene x environment effects. Adult 
      control males show reduced physiological stress response as a result of 
      gonadectomy, but not adult Wa-1 males. In females, pubertal gonadectomy elevates 
      specific anxiety parameters only in adult control mice. There also are general 
      sex-specific effects of pubertal gonadectomy on adult stress and fear memory. 
      Surgical stress alone also induces sex- and genotype-dependent effects, albeit in 
      different behavioral parameters than those affected by gonadectomy. We conclude 
      that normal development of stress and memory processes is reliant on the levels 
      of stress and gonadal factors during puberty, the effects of which are modulated 
      by genetic factors and sex.
FAU - Koshibu, Kyoko
AU  - Koshibu K
AD  - Department of Neurobiology and Center for Neural Basis of Cognition, University 
      of Pittsburgh, Pittsburgh, PA, USA. koshibu@hifo.unizh.ch
FAU - Levitt, Pat
AU  - Levitt P
LA  - eng
GR  - HD015052/HD/NICHD NIH HHS/United States
GR  - MH45507/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070502
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Transforming Growth Factor alpha)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Conditioning, Psychological
MH  - Corticosterone/blood
MH  - Fear/psychology
MH  - Female
MH  - Fever/etiology/psychology
MH  - Linear Models
MH  - Male
MH  - Memory Disorders/etiology/*psychology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity
MH  - *Orchiectomy
MH  - *Ovariectomy
MH  - Penetrance
MH  - Sexual Maturation/*physiology
MH  - Stress, Psychological/complications/*psychology
MH  - Transforming Growth Factor alpha/*genetics/*physiology
EDAT- 2007/05/03 09:00
MHDA- 2008/04/24 09:00
CRDT- 2007/05/03 09:00
PHST- 2007/05/03 09:00 [pubmed]
PHST- 2008/04/24 09:00 [medline]
PHST- 2007/05/03 09:00 [entrez]
AID - 1301436 [pii]
AID - 10.1038/sj.npp.1301436 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2008 Feb;33(3):557-65. doi: 10.1038/sj.npp.1301436. Epub 
      2007 May 2.