PMID- 17474080
OWN - NLM
STAT- MEDLINE
DCOM- 20070716
LR  - 20191210
IS  - 0951-4198 (Print)
IS  - 0951-4198 (Linking)
VI  - 21
IP  - 11
DP  - 2007
TI  - Simultaneous determination of psychotropic phenylalkylamine derivatives in human 
      hair by gas chromatography/mass spectrometry.
PG  - 1705-20
AB  - A gas chromatography/mass spectrometric (GC/MS) method was developed and 
      validated for the determination of thirteen psychotropic phenylalkylamine 
      derivatives (amphetamine; AP, phentermine; PT, methamphamine; MA, cathinone; 
      Khat, methcathinone; MCAT, fenfluramine; FFA, desmethylselegiline; DSEL, 
      3,4-methylenedioxyamphetamine; MDA, 3,4-methylenedioxymethamphetamine; MDMA, 
      3,4-methylenedioxyethylamphetamine; MDEA, norketamine; NKT, mescaline; MES, 
      4-bromo-2,5-dimethoxyphenethylamine; 2CB) in human hair. Hair samples (20 mg) 
      were washed with distilled water and acetone, cut into small fragments (<1 mm), 
      and incubated in 0.25 M methanolic HCl under ultrasonication at 50 degrees C for 
      1 h. The resulting solutions were evaporated to dryness, derivatized using 
      trifluoroacetic anhydride (TFAA) at 70 degrees C for 30 min, and analyzed by 
      GC/MS. The linear ranges were 0.02-25.0 ng/mg for AP, PT, Khat, FFA, DSEL, MDMA, 
      and 2CB; 0.05-25.0 ng/mg for MA, MCAT, and MES; 0.05-12.5 ng/mg for MDA; and 
      0.1-25.0 ng/mg for MDEA and NKT, with good correlation coefficients (r(2) > 
      0.9985). The intra-day, inter-day, and inter-person precisions were within 12.7%, 
      14.8%, and 16.8%, respectively. The intra-day, inter-day, and inter-person 
      accuracies were between -10.7 and 13.4%, -12.7 and 11.6%, and -15.3 and 11.9%, 
      respectively. The limits of quantifications (LOQs) for each compound were lower 
      than 0.08 ng/mg. The recoveries were in the range of 76.7-95.6%. The method 
      proved to be suitable for the simultaneous qualification and quantification of 
      phenylalkylamine derivatives in hair specimens.
FAU - Kim, Jin Young
AU  - Kim JY
AD  - Drug Analysis Laboratory, Forensic Science Division, Supreme Prosecutors' Office, 
      Seocho-ggu, Seoul, Korea. paxus@spo.go.kr
FAU - Jung, Kyu Sung
AU  - Jung KS
FAU - Kim, Min Kyoung
AU  - Kim MK
FAU - Lee, Jae Il
AU  - Lee JI
FAU - In, Moon Kyo
AU  - In MK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Illicit Drugs)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Solutions)
SB  - IM
MH  - Adult
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hair/*chemistry
MH  - Humans
MH  - Illicit Drugs/*analysis
MH  - Indicators and Reagents
MH  - Male
MH  - Psychotropic Drugs/*analysis
MH  - Quality Control
MH  - Reproducibility of Results
MH  - Solutions
MH  - *Substance Abuse Detection
EDAT- 2007/05/03 09:00
MHDA- 2007/07/17 09:00
CRDT- 2007/05/03 09:00
PHST- 2007/05/03 09:00 [pubmed]
PHST- 2007/07/17 09:00 [medline]
PHST- 2007/05/03 09:00 [entrez]
AID - 10.1002/rcm.3010 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2007;21(11):1705-20. doi: 10.1002/rcm.3010.