PMID- 17474805
OWN - NLM
STAT- MEDLINE
DCOM- 20070510
LR  - 20190902
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 68
IP  - 4
DP  - 2007 Apr
TI  - Increased plasma concentration of brain-derived neurotrophic factor with 
      electroconvulsive therapy: a pilot study in patients with major depression.
PG  - 512-7
AB  - OBJECTIVE: The therapeutic mechanism of electroconvulsive therapy (ECT) is 
      unknown. Animal research supports a neurotrophic effect of ECT. To investigate a 
      neurotrophic effect in humans, we examined whether plasma concentration of 
      brain-derived neurotrophic factor (BDNF) increases in patients receiving ECT for 
      major depression. METHOD: We conducted a prospective, self-controlled study of 15 
      patients with a DSM-IV diagnosis of major depressive episode who were referred 
      for ECT at the University of Maryland Medical Center (Baltimore, Md.) between 
      January 2004 and September 2005. Plasma BDNF concentration was measured by 
      enzyme-linked immunosorbent assay before and during an acute course of ECT. 
      Depression severity was measured using the 21-item Hamilton Rating Scale for 
      Depression (HAM-D). RESULTS: ECT resulted in a significant increase in plasma 
      BDNF (Z = 2.897, p = .004) from a pre-ECT median of 84.9 pg/mL to a post-ECT 
      median of 141.2 pg/mL. This change was accompanied by a significant decrease in 
      HAM-D score (Z = 3.411, p = .001) from a pre-ECT median of 30.0 to a post-ECT 
      median of 9.0. BDNF increased in 13 (86.7%) of 15 subjects. CONCLUSION: This is 
      the first report of an increase in plasma BDNF concentration in patients 
      receiving ECT. These preliminary results encourage further investigation of a 
      neurotrophic mechanism for the antidepressant effect of ECT.
FAU - Marano, Christopher M
AU  - Marano CM
AD  - Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 
      USA.
FAU - Phatak, Pornima
AU  - Phatak P
FAU - Vemulapalli, Ugandhar Rao
AU  - Vemulapalli UR
FAU - Sasan, Amritpal
AU  - Sasan A
FAU - Nalbandyan, Maria R
AU  - Nalbandyan MR
FAU - Ramanujam, Sailakshmi
AU  - Ramanujam S
FAU - Soekadar, Surjo
AU  - Soekadar S
FAU - Demosthenous, Maria
AU  - Demosthenous M
FAU - Regenold, William T
AU  - Regenold WT
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*therapy
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
EDAT- 2007/05/04 09:00
MHDA- 2007/05/11 09:00
CRDT- 2007/05/04 09:00
PHST- 2007/05/04 09:00 [pubmed]
PHST- 2007/05/11 09:00 [medline]
PHST- 2007/05/04 09:00 [entrez]
AID - 10.4088/jcp.v68n0404 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2007 Apr;68(4):512-7. doi: 10.4088/jcp.v68n0404.