PMID- 17475218
OWN - NLM
STAT- MEDLINE
DCOM- 20070727
LR  - 20211203
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 358
IP  - 1
DP  - 2007 Jun 22
TI  - MicroRNA expression profiles in head and neck cancer cell lines.
PG  - 12-7
AB  - Non-coding RNA molecules such as microRNAs (miRNAs) may play an important role in 
      human carcinogenesis. Their expression has been profiled in many human cancers 
      but there are few published studies in head and neck cancer. In this study, the 
      relative expression of 261 mature miRNA genes was determined in nine head and 
      neck cancer cell lines using an oligonucleotide array platform. Thirty-three 
      miRNAs in the array were found to be highly expressed and 22 showed low levels of 
      expression in all cell lines. Notable was the high expression of miR-21 and 
      miR-205. Expression of several miRNAs was validated using Northern blot analysis. 
      Potential targets of validated miRNAs included tumor suppressor genes, kinesin 
      family member 1B isoform alpha (KIF1B), and hypermethylated in cancer 2 (HIC2), 
      and pleomorphic adenoma gene 1 (PLAG1). This study provides the largest 
      genomewide survey of mature miRNA transcripts in head and neck cancer cell lines.
FAU - Tran, Nham
AU  - Tran N
AD  - The Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Level 6 
      Gloucester House, Royal Prince Alfred Hospital, Missenden Road, Camperdown, 
      Sydney, NSW 2050, Australia. ntran@med.usyd.edu.au
FAU - McLean, Tessa
AU  - McLean T
FAU - Zhang, Xiaoying
AU  - Zhang X
FAU - Zhao, Chuan Jia
AU  - Zhao CJ
FAU - Thomson, John Michael
AU  - Thomson JM
FAU - O'Brien, Christopher
AU  - O'Brien C
FAU - Rose, Barbara
AU  - Rose B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070409
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KIF1B protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PLAG1 protein, human)
RN  - EC 3.6.4.4 (Kinesins)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Cell Line, Tumor
MH  - DNA-Binding Proteins/metabolism
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - Head and Neck Neoplasms/*metabolism
MH  - Humans
MH  - Kinesins/metabolism
MH  - MicroRNAs/*metabolism
MH  - Nerve Tissue Proteins/metabolism
MH  - Oligonucleotide Array Sequence Analysis
EDAT- 2007/05/04 09:00
MHDA- 2007/07/28 09:00
CRDT- 2007/05/04 09:00
PHST- 2007/03/19 00:00 [received]
PHST- 2007/03/20 00:00 [accepted]
PHST- 2007/05/04 09:00 [pubmed]
PHST- 2007/07/28 09:00 [medline]
PHST- 2007/05/04 09:00 [entrez]
AID - S0006-291X(07)00608-0 [pii]
AID - 10.1016/j.bbrc.2007.03.201 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 Jun 22;358(1):12-7. doi: 
      10.1016/j.bbrc.2007.03.201. Epub 2007 Apr 9.