PMID- 17475756
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20181113
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 45
IP  - 10
DP  - 2007 Oct
TI  - Detection of mutations conferring resistance to linezolid in Enterococcus spp. by 
      fluorescence in situ hybridization.
PG  - 3421-3
AB  - A fluorescence in situ hybridization (FISH) assay was established to detect 
      linezolid resistance (conferred by the mutation 2576G>T in the gene coding for 
      the 23 string of the ribosomal RNA) in enterococci. The assay was evaluated with 
      106 Enterococcus isolates; it showed a sensitivity of 100% for the detection of 
      phenotypic resistance and was even able to identify a single mutated allele in 
      phenotypically linezolid-susceptible isolates.
FAU - Werner, Guido
AU  - Werner G
AD  - Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, 
      Robert-Kochstr. 8, D-89081 Ulm, Germany.
FAU - Bartel, Melanie
AU  - Bartel M
FAU - Wellinghausen, Nele
AU  - Wellinghausen N
FAU - Essig, Andreas
AU  - Essig A
FAU - Klare, Ingo
AU  - Klare I
FAU - Witte, Wolfgang
AU  - Witte W
FAU - Poppert, Sven
AU  - Poppert S
LA  - eng
PT  - Journal Article
DEP - 20070502
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (Acetamides)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Oxazolidinones)
RN  - 0 (RNA, Ribosomal, 23S)
RN  - ISQ9I6J12J (Linezolid)
SB  - IM
MH  - Acetamides/*pharmacology
MH  - Anti-Infective Agents/*pharmacology
MH  - Drug Resistance, Bacterial/*genetics
MH  - Enterococcus/*drug effects/genetics
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Linezolid
MH  - Microbial Sensitivity Tests
MH  - *Mutation
MH  - Oxazolidinones/*pharmacology
MH  - RNA, Ribosomal, 23S/genetics
MH  - Sensitivity and Specificity
PMC - PMC2045332
EDAT- 2007/05/04 09:00
MHDA- 2007/12/06 09:00
PMCR- 2008/02/01
CRDT- 2007/05/04 09:00
PHST- 2007/05/04 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/05/04 09:00 [entrez]
PHST- 2008/02/01 00:00 [pmc-release]
AID - JCM.00179-07 [pii]
AID - 0179-07 [pii]
AID - 10.1128/JCM.00179-07 [doi]
PST - ppublish
SO  - J Clin Microbiol. 2007 Oct;45(10):3421-3. doi: 10.1128/JCM.00179-07. Epub 2007 
      May 2.