PMID- 17477093
OWN - NLM
STAT- MEDLINE
DCOM- 20070608
LR  - 20151119
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 22
IP  - 127
DP  - 2007 Jan
TI  - [Fibrates and markers of inflammation].
PG  - 58-61
AB  - Inflammatory processes have important roles in the etiology of atherosclerosis. 
      Several studies have shown that elevated plasma levels of C-reactive protein 
      (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adhesions 
      molecules, monocyte chemoattractant protein-1 (MCP-1) are associated with the 
      risk of coronary heart disease. Fibrates, agonists of peroxisome 
      proliferator-activated receptors alpha (PPARalpha), act to modulate the 
      expression of key genes of lipid transport and metabolism in the liver and 
      adipose tissue. Besides the hipolipemic effects they exert pleiotropic, 
      anti-inflammatory properties downregulating expression of genes encoding acute 
      phase proteins and inflammatory cytokines. In this article, we briefly review the 
      clinical trial data on the effects of fibrates on the inflammatory markers.
FAU - Broncel, Marlena
AU  - Broncel M
AD  - Department of Internal Diseases with Clinical Pharmacology and Therapy Monitoring 
      Unit, Medical University of Lodz, Poland. ttm@ttm.org.pl
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Fibraty a markery zapalenia.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Cytokines)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Interleukin-6)
RN  - 0 (PPAR alpha)
RN  - 53PF01Q249 (Clofibric Acid)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Atherosclerosis/blood/drug therapy
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis/drug effects
MH  - Cholesterol, HDL/blood/drug effects
MH  - Cholesterol, LDL/blood/drug effects
MH  - Clofibric Acid/*therapeutic use
MH  - Cytokines/blood/drug effects
MH  - Fibrinogen/analysis/drug effects
MH  - Humans
MH  - Hypolipidemic Agents/*therapeutic use
MH  - Inflammation/*blood/*drug therapy
MH  - Interleukin-6/blood
MH  - Metabolic Networks and Pathways
MH  - PPAR alpha/*agonists/physiology
RF  - 35
EDAT- 2007/05/05 09:00
MHDA- 2007/06/09 09:00
CRDT- 2007/05/05 09:00
PHST- 2007/05/05 09:00 [pubmed]
PHST- 2007/06/09 09:00 [medline]
PHST- 2007/05/05 09:00 [entrez]
PST - ppublish
SO  - Pol Merkur Lekarski. 2007 Jan;22(127):58-61.