PMID- 1747750
OWN - NLM
STAT- MEDLINE
DCOM- 19920122
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 557
IP  - 1-2
DP  - 1991 Aug 23
TI  - Psychological stress increases dopamine turnover selectively in mesoprefrontal 
      dopamine neurons of rats: reversal by diazepam.
PG  - 154-61
AB  - The effects of psychological stress on catecholamine and indoleamine metabolism 
      were examined in various brain regions of rats. Psychologically stressed rats 
      were exposed to emotional responses of foot-shocked rats, but were themselves 
      prevented from receiving foot-shock. Psychological stress for 30 min resulted in 
      significant increases of both 3,4-dihydroxyphenylacetic acid (DOPAC) and 
      homovanillic acid (HVA) levels in the medial prefrontal cortex (MPFC), but not in 
      other dopamine (DA) terminal fields. The levels of noradrenaline (NA), serotonin 
      (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were unaffected in all brain 
      regions examined after 30 min of psychological stress. A small but significant 
      increase of DOPAC levels in the ventral tegmental area (VTA) was observed after a 
      shorter (10 min) duration of stress. Moreover, an increase of DOPAC levels in the 
      MPFC 30 min after psychological stress was attenuated by diazepam (5 mg/kg), and 
      this attenuating effect was antagonized by Ro 15-1788 (15 mg/kg). These results 
      suggest that mesoprefrontal DA neurons are selectively activated by psychological 
      stress, and that the activation of the A10 cell body site (VTA) may precede that 
      of the terminal field (MPFC). Moreover, diazepam was found to possess an 
      inhibitory effect on the activation of mesoprefrontal DA neurons induced by 
      psychological stress, and this effect may be partly mediated by benzodiazepine 
      (BZD) receptors and implicated in the specific anxiolytic action of BZDs.
FAU - Kaneyuki, H
AU  - Kaneyuki H
AD  - Department of Pharmacology, Kurume University School of Medicine, Japan.
FAU - Yokoo, H
AU  - Yokoo H
FAU - Tsuda, A
AU  - Tsuda A
FAU - Yoshida, M
AU  - Yoshida M
FAU - Mizuki, Y
AU  - Mizuki Y
FAU - Yamada, M
AU  - Yamada M
FAU - Tanaka, M
AU  - Tanaka M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Catecholamines)
RN  - 0 (Indoles)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 40P7XK9392 (Flumazenil)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - VTD58H1Z2X (Dopamine)
RN  - W980KJ009P (Corticosterone)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Catecholamines/metabolism
MH  - Corticosterone/blood
MH  - Diazepam/*pharmacology
MH  - Dopamine/*metabolism/physiology
MH  - Electroshock
MH  - Flumazenil/pharmacology
MH  - Frontal Lobe/anatomy & histology/cytology/*metabolism
MH  - Homovanillic Acid/metabolism
MH  - Indoles/metabolism
MH  - Male
MH  - Nerve Endings/drug effects/metabolism
MH  - Neurons/drug effects/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stress, Psychological/*metabolism
MH  - Tegmentum Mesencephali/drug effects/metabolism
EDAT- 1991/08/23 00:00
MHDA- 1991/08/23 00:01
CRDT- 1991/08/23 00:00
PHST- 1991/08/23 00:00 [pubmed]
PHST- 1991/08/23 00:01 [medline]
PHST- 1991/08/23 00:00 [entrez]
AID - 0006-8993(91)90129-J [pii]
AID - 10.1016/0006-8993(91)90129-j [doi]
PST - ppublish
SO  - Brain Res. 1991 Aug 23;557(1-2):154-61. doi: 10.1016/0006-8993(91)90129-j.