PMID- 17479445
OWN - NLM
STAT- MEDLINE
DCOM- 20070912
LR  - 20221207
IS  - 0947-7349 (Print)
IS  - 0947-7349 (Linking)
VI  - 115
IP  - 4
DP  - 2007 Apr
TI  - The peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene 
      (PGC-1alpha) is not associated with type 2 diabetes mellitus or body mass index 
      among Hispanic and non Hispanic Whites from Colorado.
PG  - 268-75
AB  - The objective of the study was to test for an association between type 2 diabetes 
      mellitus (T2DM) and body mass index (BMI) and three single nucleotide 
      polymorphisms (SNP)s in the peroxisome proliferator-activated receptor gamma 
      coactivator-1 alpha (PGC-1alpha) gene. We were also interested in whether these 
      associations differed by tertiles of diet, physical activity or presence of 
      polymorphisms in the peroxisome proliferator-activated receptor gamma 
      (PPAR-gamma) gene among Hispanics and Non-Hispanic Whites (NHW) from Colorado. We 
      studied 216 Hispanic pedigrees (1850 nuclear families) and 236 NHW pedigrees 
      (1240 families) from the San Luis Valley and Denver. We genotyped the Gly482Ser, 
      Thr528Thr and Thr612Met polymorphisms in the PGC-1alpha gene and the Pro12Ala 
      polymorphism of the PPAR-gamma gene. Historical physical activity (average 
      METS/week) as well as average dietary intake over the past year was assessed by 
      self-report. Data were analyzed using the Family Based Association Test (FBAT) as 
      well as generalized estimating equations (GEE). We did not find any significant 
      association between three SNPs in the PGC-1alpha gene and T2DM in Hispanics or 
      NHW; however, using FBAT, we found the common Thr612Thr allele of the PGC-1alpha 
      gene to be associated with T2DM among Hispanic subjects carrying the rare 
      Pro12Ala allele of the PPAR-gamma gene (p=.003). We found similar associations 
      when we considered a haplotype containing that allele (p=.002). However, the 
      results of the GEE analysis did not confirm these findings: odds ratio (OR)=1.68, 
      95% CI (0.5, 5.2) suggesting these results may due to chance. BMI also did not 
      show any consistent associations with the PGC-1alpha gene. In conclusion, we did 
      not find an association between the PGC-1alpha gene and T2DM or BMI and there 
      were no consistent interactions with diet, physical activity or the Pro12Ala 
      polymorphism of the PPAR-gamma gene.
FAU - Nelson, T L
AU  - Nelson TL
AD  - Department of Health and Exercise Science, Colorado State University, Fort 
      Collins, CO 80523, USA.
FAU - Fingerlin, T E
AU  - Fingerlin TE
FAU - Moss, L
AU  - Moss L
FAU - Barmada, M M
AU  - Barmada MM
FAU - Ferrell, R E
AU  - Ferrell RE
FAU - Norris, J M
AU  - Norris JM
LA  - eng
GR  - K01 DK-64647-01/DK/NIDDK NIH HHS/United States
GR  - M01 RR00051/RR/NCRR NIH HHS/United States
GR  - R01 DK-49632/DK/NIDDK NIH HHS/United States
GR  - R01 DK-54981/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (DNA Primers)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amino Acid Substitution
MH  - Body Mass Index
MH  - Colorado
MH  - DNA Primers
MH  - Diabetes Mellitus, Type 2/*blood/genetics/physiopathology
MH  - Female
MH  - Genotype
MH  - Heat-Shock Proteins/*genetics
MH  - Hispanic or Latino
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Polymorphism, Genetic
MH  - Transcription Factors/*genetics
MH  - White People
EDAT- 2007/05/05 09:00
MHDA- 2007/09/13 09:00
CRDT- 2007/05/05 09:00
PHST- 2007/05/05 09:00 [pubmed]
PHST- 2007/09/13 09:00 [medline]
PHST- 2007/05/05 09:00 [entrez]
AID - 10.1055/s-2007-960495 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2007 Apr;115(4):268-75. doi: 10.1055/s-2007-960495.