PMID- 17479719
OWN - NLM
STAT- MEDLINE
DCOM- 20070524
LR  - 20161124
IS  - 1079-7440 (Print)
IS  - 1079-7440 (Linking)
VI  - 61
IP  - 2
DP  - 2007 Mar-Apr
TI  - Preparation and characterization of solid lipid nanoparticles loaded with total 
      flavones of Hippophae rhamnoides (TFH).
PG  - 110-20
AB  - Solid lipid nanoparticles (SLNs) containing total flavones of Hippophae 
      rhamnoides (TFH) were prepared by high-pressure homogenization (HPH), by both hot 
      HPH and cold HPH. The influence of process parameters (lipid matrix, lipid 
      concentration, carbohydrate type and its concentration) on the SLN size 
      distribution, zeta potential, entrapment efficiency, crystal form, and in vitro 
      release profile was investigated. The highest entrapment efficiency for TFH, at 
      around 93%, was found for SLNs composed of TFH/Compritol 888 ATO in a 1:30 molar 
      ratio and made by cold HPH. The advantages of TFH SLNs are the improved oral 
      bioavailability of TFH and the prolonged mean retention time and drug release 
      time.
FAU - Wang, Dongkai
AU  - Wang D
AD  - Shenyang Pharmaceutical University, Shengyang, Liaoning, China. wangdksy@126.com
FAU - Zhao, Peng
AU  - Zhao P
FAU - Cuia, Fude
AU  - Cuia F
FAU - Li, Xiang
AU  - Li X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - PDA J Pharm Sci Technol
JT  - PDA journal of pharmaceutical science and technology
JID - 9439538
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 0 (Flavones)
RN  - 0 (Flavonols)
RN  - 0 (Lipids)
RN  - 0 (Powders)
RN  - 07X3IB4R4Z (3-methylquercetin)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Biological Availability
MH  - Chemistry, Pharmaceutical
MH  - Delayed-Action Preparations
MH  - Desiccation
MH  - Dogs
MH  - *Drug Carriers
MH  - Drug Compounding
MH  - Drug Stability
MH  - Flavones/administration & dosage/blood/*chemistry/isolation & 
      purification/pharmacokinetics
MH  - Flavonols/chemistry
MH  - Freezing
MH  - *Hippophae/chemistry
MH  - Lipids/*chemistry
MH  - *Nanoparticles
MH  - Particle Size
MH  - Powders
MH  - Pressure
MH  - Quercetin/chemistry
MH  - Solubility
MH  - *Technology, Pharmaceutical/methods
MH  - Temperature
MH  - Time Factors
EDAT- 2007/05/08 09:00
MHDA- 2007/05/26 09:00
CRDT- 2007/05/08 09:00
PHST- 2007/05/08 09:00 [pubmed]
PHST- 2007/05/26 09:00 [medline]
PHST- 2007/05/08 09:00 [entrez]
PST - ppublish
SO  - PDA J Pharm Sci Technol. 2007 Mar-Apr;61(2):110-20.