PMID- 17480175
OWN - NLM
STAT- MEDLINE
DCOM- 20070517
LR  - 20191110
IS  - 1744-764X (Electronic)
IS  - 1474-0338 (Linking)
VI  - 6
IP  - 3
DP  - 2007 May
TI  - The adverse effects of antiepileptic drugs in children.
PG  - 251-65
AB  - Efficacy of antiepileptic drugs (AEDs) are often equivalent, hence selection of 
      an AED is often determined by the adverse effects (AEs). The development of 
      neurocognitive AEs is almost inevitable with use of AEDs, especially in high-risk 
      groups. Teratogenesis with major or minor malformations is of great concern 
      during the first trimester of pregnancy, but an increasing body of information 
      suggests that potential neurocognitive developmental delay may also occur with 
      use of AEDs in the latter part of pregnancy. Decreased bone mineral density has 
      been found in adults and children receiving both enzyme-inducing AEDs and 
      valproate, an enzyme-inhibiting drug. AEDs may influence the lipid profile, body 
      weight, reproductive, hormonal and other endocrine functions, and sleep 
      architecture. There are age-specific AEs related to pharmacokinetic differences 
      that have been highlighted in this review with emphasis on the pediatric 
      population. A classification of AEs using different parameters is also included.
FAU - Kothare, Sanjeev V
AU  - Kothare SV
AD  - St Christopher's Hospital for Children, Section of Neurology, Department of 
      Pediatrics, Drexel University College of Medicine, Philadelphia, PA 19134, USA. 
      skothare@drexelmed.edu
FAU - Kaleyias, Joseph
AU  - Kaleyias J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Drug Saf
JT  - Expert opinion on drug safety
JID - 101163027
RN  - 0 (Anticonvulsants)
RN  - 0 (Lipids)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology
MH  - Anticonvulsants/*adverse effects
MH  - Blood Cells/drug effects
MH  - Body Weight/drug effects
MH  - Bone Density/drug effects
MH  - Child
MH  - Cognition/drug effects
MH  - Female
MH  - Fetus/drug effects
MH  - Humans
MH  - Lipids/blood
MH  - Pregnancy
MH  - Reproduction/drug effects
MH  - Sleep/drug effects
RF  - 133
EDAT- 2007/05/08 09:00
MHDA- 2007/05/18 09:00
CRDT- 2007/05/08 09:00
PHST- 2007/05/08 09:00 [pubmed]
PHST- 2007/05/18 09:00 [medline]
PHST- 2007/05/08 09:00 [entrez]
AID - 10.1517/14740338.6.3.251 [doi]
PST - ppublish
SO  - Expert Opin Drug Saf. 2007 May;6(3):251-65. doi: 10.1517/14740338.6.3.251.