PMID- 1748088
OWN - NLM
STAT- MEDLINE
DCOM- 19920123
LR  - 20191021
IS  - 0893-6692 (Print)
IS  - 0893-6692 (Linking)
VI  - 18
IP  - 4
DP  - 1991
TI  - DNA sequence mapping by fluorescence in situ hybridization.
PG  - 259-62
AB  - Various types of DNA probes, such as total genomic DNA, repetitive sequences, 
      unique sequences, and composites of chromosome-specific DNA probes, can be used 
      with fluorescence in situ hybridization (FISH) techniques to address research 
      questions having to do with localization, mapping, and distribution of DNA in 
      situ. FISH involves the formation of a heteroduplex between such DNA probes and 
      chromatin targets on a microscope slide, which can be visualized with fluorescent 
      reporter molecules. Three chromatin targets--metaphase chromosomes, somatic 
      interphases, and zygote interphases--offer increasingly extended states of 
      chromatin which can be strategically selected, individually or in combination, to 
      address specific research questions of interest.
FAU - Brandriff, B F
AU  - Brandriff BF
AD  - Lawrence Livermore National Laboratory, University of California 94550.
FAU - Gordon, L A
AU  - Gordon LA
FAU - Trask, B J
AU  - Trask BJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Environ Mol Mutagen
JT  - Environmental and molecular mutagenesis
JID - 8800109
RN  - 0 (DNA Probes)
SB  - IM
MH  - *Chromosome Mapping/methods
MH  - DNA Probes
MH  - Humans
MH  - Microscopy, Fluorescence
MH  - Nucleic Acid Hybridization
RF  - 20
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1002/em.2850180410 [doi]
PST - ppublish
SO  - Environ Mol Mutagen. 1991;18(4):259-62. doi: 10.1002/em.2850180410.