PMID- 17482097
OWN - NLM
STAT- MEDLINE
DCOM- 20071023
LR  - 20220331
IS  - 1050-1738 (Print)
IS  - 1050-1738 (Linking)
VI  - 17
IP  - 4
DP  - 2007 May
TI  - Brain-derived neurotrophic factor: a newly described mediator of angiogenesis.
PG  - 140-3
AB  - Recent studies indicate that, in addition to its neuropoietic actions, brain 
      derived neurotrophic factor (BDNF) promotes endothelial cell survival and induces 
      neoangiogenesis in ischemic tissues. Unlike many vascular growth factors that act 
      on many vascular beds, BDNF activity is relatively restricted to central 
      arteries, vessels of cardiac and skeletal muscle, and skin. Studies of newly 
      described biologic mediators that act on large-vessel and microvascular beds in 
      these organs will help us to better understand organ-specific vascular 
      development, as well as to develop novel therapeutic strategies to improve the 
      condition of patients with cardiac and peripheral vascular disease. In this 
      review, we summarize dual proangiogenic actions of BDNF, which, through local 
      activation of TrkB receptor, expressed on a subpopulation of endothelial cells 
      and, in addition, by recruitment of bone marrow-derived cells, contribute to 
      neoangiogenesis.
FAU - Kermani, Pouneh
AU  - Kermani P
AD  - Department of Medicine, Weill Medical College of Cornell University, 1300 York 
      Avenue, NY, NY 10021, USA.
FAU - Hempstead, Barbara
AU  - Hempstead B
LA  - eng
GR  - P01 HL046403/HL/NHLBI NIH HHS/United States
GR  - HL059312/HL/NHLBI NIH HHS/United States
GR  - HL072942/HL/NHLBI NIH HHS/United States
GR  - P01 HL046403-150008/HL/NHLBI NIH HHS/United States
GR  - P01 HL059312/HL/NHLBI NIH HHS/United States
GR  - P01 HL059312-060007/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Trends Cardiovasc Med
JT  - Trends in cardiovascular medicine
JID - 9108337
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Angiogenesis Inducing Agents/metabolism
MH  - Bone Marrow Cells
MH  - Brain-Derived Neurotrophic Factor/*metabolism/*therapeutic use
MH  - Endothelial Cells/metabolism
MH  - Humans
MH  - Ischemia/etiology/*therapy
MH  - Neovascularization, Pathologic/*etiology/therapy
MH  - Receptor, trkB
MH  - Regeneration
PMC - PMC2268985
MID - NIHMS23333
EDAT- 2007/05/08 09:00
MHDA- 2007/10/24 09:00
PMCR- 2008/03/19
CRDT- 2007/05/08 09:00
PHST- 2006/12/11 00:00 [received]
PHST- 2007/03/22 00:00 [accepted]
PHST- 2007/05/08 09:00 [pubmed]
PHST- 2007/10/24 09:00 [medline]
PHST- 2007/05/08 09:00 [entrez]
PHST- 2008/03/19 00:00 [pmc-release]
AID - S1050-1738(07)00076-X [pii]
AID - 10.1016/j.tcm.2007.03.002 [doi]
PST - ppublish
SO  - Trends Cardiovasc Med. 2007 May;17(4):140-3. doi: 10.1016/j.tcm.2007.03.002.