PMID- 17482146
OWN - NLM
STAT- MEDLINE
DCOM- 20071026
LR  - 20131121
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 62
IP  - 5
DP  - 2007 Sep 1
TI  - Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) 
      on depression in Korean elders.
PG  - 423-8
AB  - BACKGROUND: It has been reported that the functional polymorphism in the 
      serotonin transporter gene linked promoter region (5-HTTLPR) modifies the 
      association between stressful life events (SLEs) and depression in child, 
      adolescent, and adult populations. We sought to replicate this finding in elders 
      and, additionally, to test modifying effects of the brain-derived neurotrophic 
      factor (BDNF) val66met polymorphism. METHODS: In 732 Korean community residents 
      ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information 
      on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained. Of those 
      without depression at baseline, 521 (88%) were followed up 2.5 years later. 
      Interactions between SLEs and the two genotypes were investigated for both 
      prevalent depression at baseline and incident depression at follow-up. RESULTS: 
      Significant interactions of SLEs with both 5-HTTLPR and BDNF genotypes were 
      observed on risk of depression after adjustment for age, gender, education, and 
      disability. A significant three-way interaction between 5-HTTLPR, BDNF, and SLEs 
      was also found. The same findings were observed for predictors of incident 
      depression in the prospective analysis. CONCLUSIONS: These findings suggest that 
      environmental risk of depression is modified by at least two genes and that 
      gene-environment interactions are found even into old age.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry & Depression Clinical Research Center, Chonnam National 
      University Medical School, Kwangju, Korea.
FAU - Stewart, Robert
AU  - Stewart R
FAU - Kim, Sung-Wan
AU  - Kim SW
FAU - Yang, Su-Jin
AU  - Yang SJ
FAU - Shin, Il-Seon
AU  - Shin IS
FAU - Kim, Young-Hoon
AU  - Kim YH
FAU - Yoon, Jin-Sang
AU  - Yoon JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070504
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Depression/complications/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Geriatrics
MH  - Humans
MH  - Korea
MH  - Male
MH  - Methionine/genetics
MH  - *Polymorphism, Genetic
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Stress, Psychological/complications/*genetics
MH  - Valine/genetics
EDAT- 2007/05/08 09:00
MHDA- 2007/10/30 09:00
CRDT- 2007/05/08 09:00
PHST- 2006/09/18 00:00 [received]
PHST- 2006/11/17 00:00 [revised]
PHST- 2006/11/23 00:00 [accepted]
PHST- 2007/05/08 09:00 [pubmed]
PHST- 2007/10/30 09:00 [medline]
PHST- 2007/05/08 09:00 [entrez]
AID - S0006-3223(06)01509-5 [pii]
AID - 10.1016/j.biopsych.2006.11.020 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2007 Sep 1;62(5):423-8. doi: 10.1016/j.biopsych.2006.11.020. 
      Epub 2007 May 4.