PMID- 17483907
OWN - NLM
STAT- MEDLINE
DCOM- 20071121
LR  - 20181113
IS  - 0957-4530 (Print)
IS  - 0957-4530 (Linking)
VI  - 18
IP  - 9
DP  - 2007 Sep
TI  - Degradation and drug release properties of 
      poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene 
      carbonate).
PG  - 1765-9
AB  - A series of biodegradable amphiphilic graft copolymers with 
      poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) as the backbone and 
      poly(2,2-dimethyltrimethylene carbonate) (PDTC) segments with different lengths 
      as the grafted branches were synthesized and characterized. The in vitro 
      degradation of the obtained PHEA-g-PDTC copolymers was studied. With particular 
      branch lengths, PHEA-g-PDTC can form self-assembling micelles in an aqueous 
      solution. Transmission electron microscopy (TEM) images demonstrated that the 
      micelles were regularly spherical in shape. The particle size and distribution of 
      the micelles were measured. Nanoparticle drug delivery systems were prepared by 
      the direct dissolution method. The in vitro release behaviors of two drugs, 
      prednisone acetate and tegafur, with different water solubilities were 
      investigated.
FAU - Peng, Tao
AU  - Peng T
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education, Department of 
      Chemistry, Wuhan University, Wuhan, PR China.
FAU - Su, Jing
AU  - Su J
FAU - Cheng, Si-Xue
AU  - Cheng SX
FAU - Zhuo, Ren-Xi
AU  - Zhuo RX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070505
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Biocompatible Materials)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Peptides)
RN  - 0 (Polymers)
RN  - 0 (alpha,beta-poly((2-hydroxyethyl)-aspartamide))
RN  - 059QF0KO0R (Water)
RN  - 1548R74NSZ (Tegafur)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Biocompatible Materials/chemical synthesis/*chemistry
MH  - Delayed-Action Preparations
MH  - Drug Delivery Systems
MH  - Microscopy, Electron, Transmission
MH  - Nanoparticles/chemistry/ultrastructure
MH  - Peptides/chemical synthesis/*chemistry
MH  - Polymers/chemical synthesis/*chemistry
MH  - Prednisone/administration & dosage
MH  - Solubility
MH  - Tegafur/administration & dosage
MH  - Water
EDAT- 2007/05/08 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/05/08 09:00
PHST- 2005/08/08 00:00 [received]
PHST- 2006/05/05 00:00 [accepted]
PHST- 2007/05/08 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/05/08 09:00 [entrez]
AID - 10.1007/s10856-007-3022-9 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2007 Sep;18(9):1765-9. doi: 10.1007/s10856-007-3022-9. 
      Epub 2007 May 5.