PMID- 17484621
OWN - NLM
STAT- MEDLINE
DCOM- 20070920
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 45
IP  - 5
DP  - 2007
TI  - HLA-DQA1 and -DQB1 allele typing in southern Taiwanese women with breast cancer.
PG  - 611-4
AB  - BACKGROUND: The pathogenesis of breast cancer is multifactorial. Genetic 
      predisposition, environmental factors, hormones and even infection agents are 
      thought to interact in the manifestation of breast cancer. In particular, human 
      leukocyte antigen (HLA) alleles play a pivotal role in cellular immunity and may 
      be an important genetically determined host trait. Regardless of the importance 
      and functions of HLA genes in the evolution of cancer, the allele-specific 
      association of HLA molecules in cancer patients has not been well established. 
      Recently, a few studies have concentrated on the association between HLA and 
      breast cancer, but the results of these studies are controversial. METHODS: We 
      designed a study to evaluate the association between the genotype of HLA class II 
      genes and breast cancer. HLA-DQA1 and -DQB1 polymorphisms were determined by PCR 
      with sequence-specific primers (PCR-SSP) in 101 Taiwanese women patients with 
      breast cancer and 115 matched control subjects. RESULTS: Using PCR-SSP typing, 
      HLA-DQA1 and -DQB1 locus comparison of allele frequencies between breast cancer 
      patients and healthy controls showed no significant difference. CONCLUSIONS: We 
      have established a significant lack of HLA-DQA1 and -DQB1 association with breast 
      cancer in southern Taiwanese women. The results of this study may provide 
      information for further clarification of the etiology of breast cancer in this 
      region.
FAU - Chen, Po-Chih
AU  - Chen PC
AD  - Department of Laboratory Medicine, Kaohsiung Medical University Chung-Ho, 
      Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Tsai, Eing-Mei
AU  - Tsai EM
FAU - Er, Tze-Kiong
AU  - Er TK
FAU - Chang, Su-Jen
AU  - Chang SJ
FAU - Chen, Bai-Hsiun
AU  - Chen BH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - Breast Neoplasms/epidemiology/etiology/*genetics
MH  - Case-Control Studies
MH  - Classification
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Middle Aged
MH  - Molecular Epidemiology
MH  - Polymerase Chain Reaction
MH  - Taiwan/epidemiology
EDAT- 2007/05/09 09:00
MHDA- 2007/09/21 09:00
CRDT- 2007/05/09 09:00
PHST- 2007/05/09 09:00 [pubmed]
PHST- 2007/09/21 09:00 [medline]
PHST- 2007/05/09 09:00 [entrez]
AID - 10.1515/CCLM.2007.132 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2007;45(5):611-4. doi: 10.1515/CCLM.2007.132.